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Objectives: In most of the emergency trauma intensive care units (ICUs) of India, neurosurgical opinion is sought for patients presenting with head trauma after earliest possible resuscitation to determine the further line of management. This study aimed to identify common risk factors, leading to neurological deterioration in conservatively managed patients of traumatic brain injury (TBI). Materials and Methods: This retrospective study analyzed patients admitted with acute TBI and traumatic intracranial hematoma under emergency trauma care ICU who did not require neurosurgical operation within 48 h of trauma. The recorded data were analyzed to determine the predictors of neurological deterioration using univariate and binary logistic regression analysis in SPSS-16 software. Results: Medical records of consecutive 275 patients of acute TBI presenting to the emergency department were studied. One hundred and ninety-three patients were afflicted with mild TBI (70.18%), 49 patients had moderate TBI (17.81%), and 33 had severe TBI (12%). In the outcome, 74.54% of patients were discharged, and operative decision was made on 6.18% of patients and 19.27% died. Severe TBI is the independent predictor of neurological deterioration during their stay in ICU. Progressive hemorrhagic injury (PHI) showed neurological deterioration in 86.5% of patients. Systemic inflammatory response syndrome (SIRS) was present in 93.5% of patients who had deteriorated neurologically. Dyselectrolytemia was the biochemical derangements seen in 24.36% of cases. Conclusion: This study revealed severe TBI, PHI, and SIRS to be strong and independent risk factors of neurological deterioration.
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Introduction: Remdesivir and Tocilizumab are two experimental drugs used in severely ill COVID-19 patients. Various clinical trials studying these drugs are giving conflicting results. Our aim is to study these two drugs and share the experience in our setting. Methods: Our Study is a retrospective analysis of Clinico-laboratory details and outcome of three groups of patients who were given either (i) Remdesivir or (ii) Tocilizumab or (iii)both Remdesivir and Tocilizumab . We compared the outcome of these patients with other patients who did not receive either of these drugs, when it was not available or not introduced as experimental drugs earlier in treatment guidelines. Results: Out of a total of 521 patients, in the above three groups who received either or both Remdesivir or Tocilizumab, 334 survived. Out of 214 patients who did not receive any of the two drugs only 74 survived. The outcome was better individually for all the three groups of patients receiving either or both of the drugs as compared to neither of the drugs.(p <0.01) Conclusion: Remdesivir and Tocilizumab were useful drugs in treatment of severely ill covid -19 patients as compared with the patients who did not receive any of the above drugs.
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Tratamiento Farmacológico de COVID-19 , Adenosina Monofosfato/análogos & derivados , Alanina/análogos & derivados , Anticuerpos Monoclonales Humanizados , Humanos , Estudios Retrospectivos , SARS-CoV-2RESUMEN
BACKGROUND: Craniotomy and surgical clipping is the standard modality of treatment in patients of cerebral aneurysms. However, the surgical clipping of aneurysm may pose serious difficulties in the case of a bilateral carotid artery occlusion. The endovascular treatment has shown promising results in this disease. METHODS: A retrospective study of all patients of posterior circulation aneurysms in the background of carotid occlusive disease at our department was performed. The aim of this study was to describe the clinical, radiological characteristics, and the treatment of this rare entity. RESULTS: Four patients were treated from January 2009 to October 2015. The mean age of our patients was 34 years with ages that ranged from 17 to 45 without any gender predominance. The mean period between onset of symptoms and diagnosis was 6 weeks. Angiographic localization of the disease was observed in all patients. All patients were treated by endovascular techniques. The postoperative course has been satisfactory with a complete neurological recovery in all patients. CONCLUSIONS: Rupture of posterior circulation aneurysms in the setting of bilateral internal carotid artery occlusion is extremely rare. Treatment is exclusively endovascular intervention. The functional outcome of ruptured posterior circulation aneurysms in setting of bilateral carotid occlusive disease is particularly favorable with good neurological recovery.
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Guillain-Barré syndrome. GBS as initial manifestation of lupus is exceedingly rare and has been reported in a few cases in the literature. We report here a 35 year old woman who presented with 10 day history of progressive muscle weakness and paraesthesias in all four limbs. She was diagnosed as SLE with renal involvement and was treated with steroids and cyclophosphamide.
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Síndrome de Guillain-Barré/diagnóstico , Lupus Eritematoso Sistémico/diagnóstico , Adulto , Ciclofosfamida , Femenino , Humanos , Riñón , Parestesia/diagnósticoRESUMEN
We present a case of mesentric vasculitis with systemic lupus erythematosus who relapsed after high dose steroids but achieved subsequent remission after starting pulse cyclophosphamide therapy. 38 years old female who had earlier polyserositis and cerebral venous thrombosis was admitted with provisional diagnosis of SLE and developed acute abdominal pain during hospital stay. She was diagnosed as mesenteric vasculitis and initially responded to pulse methylprednisolone. However, she had relapse which subsequently responded to pulse cyclophosphamide and steroids. During the ward course she also developed acute thyroiditis and was diagnosed to have class IV lupus nephritis on renal biopsy.
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Lupus Eritematoso Sistémico/complicaciones , Mesenterio/irrigación sanguínea , Vasculitis/etiología , Adulto , Femenino , Humanos , Vasculitis/diagnósticoRESUMEN
A 22-year-old female, a known case of neurofibromatosis 1 (NF1), presented with a congenital swelling in the left occipital region. She had developed recent onset dysphagia and localized occipital headache. Neuroradiology revealed a left occipital meningoencephalocele and a left parapharyngeal meningocele. This was associated with ventriculomegaly. She was advised on cranioplasty along with duraplasty which she denied. She agreed to a lumbar-peritoneal shunt. She described a dramatic improvement in her symptoms following the lumbar-peritoneal shunt. Occipital dysplasias, though uncommon, have been reported in the literature. We review this case and its management and discuss relevant literature on occipital dysplasias in NF1.
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Trombosis de los Senos Intracraneales/diagnóstico , Trombosis de los Senos Intracraneales/etiología , Tuberculosis Meníngea/complicaciones , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Trombosis de los Senos Intracraneales/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto JovenRESUMEN
A 52-year-old female presented with frequent episodes of falls without loss of consciousness. These episodes lasted for brief period followed by full neurological recovery. Magnetic resonance imaging (MRI) of the brain showed foramen magnum meningioma encasing left vertebral artery. The patient had dramatic improvement after excision of the tumor.
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We report a 58-year-old man presenting with acute paraplegia. MRI showed a haematoma within a well-defined epidural lesion at C7-D1. Intraoperatively, organised epidural haematoma surrounded by tumour tissue was found. The final histopathology report was angiolipoma. The patient had dramatic recovery. Angiolipomas should be considered in the differential diagnosis of acute paraplegia when imaging shows well-circumscribed haematoma.
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Angiolipoma/complicaciones , Angiolipoma/diagnóstico , Paraplejía/etiología , Compresión de la Médula Espinal/diagnóstico , Neoplasias de la Columna Vertebral/diagnóstico , Accidente Cerebrovascular/etiología , Enfermedad Aguda , Angiolipoma/patología , Angiolipoma/cirugía , Biopsia con Aguja , Diagnóstico Diferencial , Imagen de Difusión por Resonancia Magnética , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Laminectomía/métodos , Masculino , Persona de Mediana Edad , Paraplejía/diagnóstico , Paraplejía/cirugía , Recuperación de la Función , Medición de Riesgo , Compresión de la Médula Espinal/etiología , Compresión de la Médula Espinal/cirugía , Neoplasias de la Columna Vertebral/complicaciones , Neoplasias de la Columna Vertebral/patología , Neoplasias de la Columna Vertebral/cirugía , Accidente Cerebrovascular/diagnóstico , Resultado del TratamientoRESUMEN
Intracranial tumors may rarely cause stroke. We report an epidermoid cyst causing stroke in a pediatric patient. We have also reviewed the literature and pathogenesis of stroke caused by intracranial tumors.
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Hemophagocytic lymphohistiocytosis (HLH), is an uncommon, life-threatening hyperinflammatory syndrome caused by severe hypercytokinemia with excessive activation of lymphocytes and macrophages due to a highly stimulated but ineffective immune process. We report a case of Hemophagocytic Lymphohistiocytosis in a 15 year old boy presenting with fever, lymphadenopathy and pancytopenia due to infection caused by Klebsiella Pneumoniae and Acinetobacter.
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Infecciones por Acinetobacter/complicaciones , Infecciones por Klebsiella/complicaciones , Klebsiella pneumoniae , Linfohistiocitosis Hemofagocítica/diagnóstico , Infecciones por Acinetobacter/diagnóstico , Infecciones por Acinetobacter/inmunología , Adolescente , Biopsia con Aguja , Médula Ósea/patología , Diagnóstico Diferencial , Humanos , India , Infecciones por Klebsiella/diagnóstico , Infecciones por Klebsiella/inmunología , Ganglios Linfáticos/patología , Linfohistiocitosis Hemofagocítica/inmunología , Masculino , Pancitopenia/diagnóstico , Pancitopenia/inmunologíaAsunto(s)
Síndrome Antifosfolípido/tratamiento farmacológico , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Lupus Eritematoso Sistémico/tratamiento farmacológico , Estrongiloidiasis/inmunología , Adulto , Animales , Antinematodos/uso terapéutico , Síndrome Antifosfolípido/complicaciones , Síndrome Antifosfolípido/diagnóstico , Heces/parasitología , Femenino , Fluidoterapia , Humanos , Ivermectina/uso terapéutico , Lupus Eritematoso Sistémico/complicaciones , Lupus Eritematoso Sistémico/diagnóstico , Esputo/parasitología , Strongyloides/aislamiento & purificación , Estrongiloidiasis/diagnóstico , Estrongiloidiasis/parasitología , Estrongiloidiasis/terapia , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
We report a 16-year-old girl who had stunted growth and primary amenorrhea presenting with headache and vomiting. MRI of brain showed posterior fossa dermoid cyst with hydrocephalus and empty sella. Growth hormone (GH), Leutinizing hormone (LH) and Follicular stimulating hormone (FSH) were grossly reduced on endocrinological work-up. She underwent suboccipital midline craniectomy and complete excision of dermoid cyst .She had no additional deficit after the surgery. She had menarche six months after the surgery and developed adequate secondary sexual characters, however her height remains subnormal at follow-up after 2 years as compared to age matched controls. We briefly review the radiological features, pathogenesis and outcome of this underestimated entity.
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Amenorrea/etiología , Quiste Dermoide/cirugía , Síndrome de Silla Turca Vacía/cirugía , Adolescente , Estatura , Encéfalo/patología , Neoplasias del Ventrículo Cerebral/complicaciones , Neoplasias del Ventrículo Cerebral/patología , Quiste Dermoide/complicaciones , Quiste Dermoide/patología , Síndrome de Silla Turca Vacía/complicaciones , Síndrome de Silla Turca Vacía/patología , Femenino , Hormona Folículo Estimulante/sangre , Hormona de Crecimiento Humana/sangre , Humanos , Hormona Luteinizante/sangre , Imagen por Resonancia Magnética , Procedimientos NeuroquirúrgicosRESUMEN
A 46-year-old female, known case of adiposis dolorosa since adolescence, noticed painful thickening of scalp in bilateral parieto-occipital areas and vertex 1 year back. Six weeks prior to the presentation to our service, she developed severe occipital headache refractory to drug treatment. She improved after bilateral greater occipital nerve blocks. She was subjected to bilateral greater occipital chemical neurolysis which has given her complete pain relief.
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Adiposis Dolorosa/diagnóstico , Trastornos de Cefalalgia/diagnóstico , Neuralgia/diagnóstico , Cuero Cabelludo/inervación , Adiposis Dolorosa/complicaciones , Adiposis Dolorosa/patología , Diagnóstico Diferencial , Femenino , Trastornos de Cefalalgia/etiología , Humanos , Persona de Mediana Edad , Neuralgia/tratamiento farmacológico , Neuralgia/patología , Cuero Cabelludo/patología , Nervios Espinales/efectos de los fármacos , Nervios Espinales/patologíaRESUMEN
Intradiploic hematomas occur rarely. They have been reported in patients with and without coagulation disorders. The presentation of intradiploic hematomas varies depending on their location and the severity of the coagulopathy. We describe a patient with a huge hemicranial chronic intradiploic hematoma. Surgery involved opening the thinned outer table and evacuation of a jelly-like material and an organized clot, leaving behind the inner table. The rarity of this disease, possible pathogenesis and related surgical aspects are discussed.