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2.
J Clin Pharmacol ; 16(4): 198-204, 1976 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-131133

RESUMEN

The effect of ipratropium bromide administered at two dosage levels, 40 and 80 mug, isoproterenol, 150 mug, and placebo using a metered dose inhaler was evaluated in ten adult patients with asthma in a double-blind, crossover study. The new atropine-like drug proved to be as effective a bronchodilator as isoproterenol in this study, although it had a later peak effect. Ipratropium bromide had a longer course of action than isoproterenol (4 hours compared to 1-2 hours) and was free of significant side effects. The larger dose of the new drug produced a slightly greater and longer-acting effect than the smaller dose. Ipratropium bromide seems to have had bronchodilator effects on both large and small airways.


Asunto(s)
Asma/tratamiento farmacológico , Derivados de Atropina , Ipratropio/uso terapéutico , Isoproterenol/uso terapéutico , Adulto , Resistencia de las Vías Respiratorias , Asma/fisiopatología , Ensayos Clínicos como Asunto , Femenino , Volumen Espiratorio Forzado , Humanos , Masculino , Curvas de Flujo-Volumen Espiratorio Máximo , Flujo Espiratorio Medio Máximo , Persona de Mediana Edad , Factores de Tiempo
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