RESUMEN
The spectrum of neurologic complications of disease of the testis and ovaries includes complications of established neoplastic and non-neoplastic disorders affecting the central nervous system (CNS) and peripheral nervous system (PNS). It also includes diverse CNS presentations that precede a known diagnosis of testis or ovarian tumors. Well-defined clinical phenotypes, imaging characteristics, and specific serum markers allow clinical recognition and search for a primary gonadal neoplasm. Androgen receptor abnormalities and primary ovarian failure frequently occur in a number of inherited disorders that also affect the CNS and PNS. Moreover, the integrity and normal function of the ovaries and testis may be affected in common neurologic disorders leading in part to infertility in male patients.
Asunto(s)
Enfermedades de los Genitales Femeninos/complicaciones , Enfermedades de los Genitales Masculinos/complicaciones , Enfermedades del Sistema Nervioso/etiología , Ovario/patología , Testículo/patología , Femenino , Humanos , MasculinoRESUMEN
Multiple endocrine syndromes are unusual familial disorders affecting multiple endocrine glands; they result from an autoimmune process, causing progressive inflammatory destruction of glandular tissue, leading to hormonal insufficiency. Neurologic manifestations result from endocrine failure and/or independent autoimmune neurologic disorders. Multiple endocrine neoplasia (MEN) results from oncogene mutations in cells derived from the neural crest with proliferation of neuroectodermal cells within endocrine glands and skin. Although most MEN-associated tumors are histologically benign, medullary carcinoma of the thyroid is invasive and potentially lethal. Neurologic symptoms may be caused by increased hormonal production and by the presence of other peripheral nervous system (PNS) and central nervous system (CNS) tumors.