RESUMEN
Parkinson's disease (PD) is challenging for clinicians to accurately diagnose in the early stages. Quantitative measures of brain health can be obtained safely and non-invasively using medical imaging techniques like magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT). For accurate diagnosis of PD, powerful machine learning and deep learning models as well as the effectiveness of medical imaging tools for assessing neurological health are required. This study proposes four deep learning models with a hybrid model for the early detection of PD. For the simulation study, two standard datasets are chosen. Further to improve the performance of the models, grey wolf optimization (GWO) is used to automatically fine-tune the hyperparameters of the models. The GWO-VGG16, GWO-DenseNet, GWO-DenseNet + LSTM, GWO-InceptionV3 and GWO-VGG16 + InceptionV3 are applied to the T1,T2-weighted and SPECT DaTscan datasets. All the models performed well and obtained near or above 99% accuracy. The highest accuracy of 99.94% and AUC of 99.99% is achieved by the hybrid model (GWO-VGG16 + InceptionV3) for T1,T2-weighted dataset and 100% accuracy and 99.92% AUC is recorded for GWO-VGG16 + InceptionV3 models using SPECT DaTscan dataset.
Asunto(s)
Algoritmos , Aprendizaje Profundo , Imagen por Resonancia Magnética , Enfermedad de Parkinson , Tomografía Computarizada de Emisión de Fotón Único , Humanos , Enfermedad de Parkinson/diagnóstico por imagen , Tomografía Computarizada de Emisión de Fotón Único/métodos , Imagen por Resonancia Magnética/métodos , Masculino , FemeninoRESUMEN
Accurate diagnosis of Parkinson's disease (PD) at an early stage is challenging for clinicians as its progression is very slow. Currently many machine learning and deep learning approaches are used for detection of PD and they are popular too. This study proposes four deep learning models and a hybrid model for the early detection of PD. Further to improve the performance of the models, grey wolf optimization (GWO) is used to automatically fine-tune the hyperparameters of the models. The simulation study is carried out using two standard datasets, T1,T2-weighted and SPECT DaTscan. The metaherustic enhanced deep learning models used are GWO-VGG16, GWO-DenseNet, GWO-DenseNet + LSTM, GWO-InceptionV3 and GWO-VGG16 + InceptionV3. Simulation results demonstrated that all the models perform well and obtained near above 99% of accuracy. The AUC-ROC score of 99.99 is achieved by the GWO-VGG16 + InceptionV3 and GWO-DenseNet models for T1, T2-weighted dataset. Similarly, the GWO-DenseNet, GWO-InceptionV3 and GWO-VGG16 + InceptionV3 models result an AUC-ROC score of 100 for SPECT DaTscan dataset.