RESUMEN
Various modes of electrostimulation of the musculus gastrocnemius (MG) were examined for effect on doppler parameters of blood flow in the popliteal artery and vein of 15 healthy subjects at the age 30.6 +/- 1.5 years. The strongest effect on the circulation in the popliteal artery was observed at the stimulation with 16-second stimulus alternating with 16-second pause. Such mode led to dilation of the artery diameter by 16.2%, maximal blood flow speed increased by 50.6%, time-averaged circulation was by 60.4% faster. Electrostimulation of the crural muscles also induced dilation of the popliteal vein and accelerated relevant circulation. These changes were also most evident in the stimulation mode 16-second stimulation intermittent with a pause.
Asunto(s)
Estimulación Eléctrica , Pierna/irrigación sanguínea , Músculo Esquelético/fisiología , Adulto , Arterias/diagnóstico por imagen , Arterias/fisiología , Femenino , Humanos , Masculino , Valores de Referencia , Ultrasonografía Doppler , Venas/diagnóstico por imagen , Venas/fisiologíaRESUMEN
Catechins and proanthocyanidins have been studied for their effect on initial stage of the protein biosynthesis. It has been found that (+)-catechin in all concentrations studied does not influence the intensity of t-RNA aminoacylation by 14C-glycine and 14C-arginine. Proanthocyanidins, namely, dimers B-3, B-6 and trimer C2 in the concentration of 10(-3) M completely inhibit the initial stage of the protein biosynthesis.
Asunto(s)
Antocianinas/farmacología , Catequina/farmacología , Hígado/efectos de los fármacos , Proantocianidinas , Biosíntesis de Proteínas , Animales , Arginina/metabolismo , Catequina/análogos & derivados , Glicina/metabolismo , Hígado/metabolismo , Masculino , Aminoacil-ARN de Transferencia/metabolismo , Ratas , Ratas WistarRESUMEN
The intensity of biosynthesis processes in animal organism has been studied as affected by long-term administration of morphine. It was established that morphine administration to rats for five weeks intensified protein biosynthesis in the brain, kidneys, skeletal muscles: specific radioactivity of blood serum proteins also increased. Incorporation of 2-/14C/glycine label to the brain, cardiac and skeletal muscles increased as affected by morphine: the label incorporation to the liver lipids decreased and that to the kidney and spleen lipids did not change. Specific radioactivity of glycogen multiply increased in the rat liver as affected by morphine.
Asunto(s)
Glucógeno/biosíntesis , Lípidos/sangre , Morfina/administración & dosificación , Biosíntesis de Proteínas , Animales , Proteínas Sanguíneas/efectos de los fármacos , Proteínas Sanguíneas/metabolismo , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Corazón/efectos de los fármacos , Riñón/efectos de los fármacos , Riñón/metabolismo , Hígado/efectos de los fármacos , Hígado/metabolismo , Masculino , Músculos/efectos de los fármacos , Músculos/metabolismo , Miocardio/metabolismo , Ratas , Ratas Wistar , Bazo/efectos de los fármacos , Bazo/metabolismo , Factores de TiempoRESUMEN
Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
Asunto(s)
Hígado/metabolismo , Morfina/envenenamiento , Animales , Ciclo del Ácido Cítrico , Metabolismo Energético , Glucólisis , Masculino , Biosíntesis de Proteínas , Aminoacil-ARN de Transferencia/metabolismo , Ratas , Ratas WistarRESUMEN
After administration of ethanol into rats at a dose of 1.63 g/kg of body mass within two weeks the rate of sRNA aminoacylation was decreased if 14C-leucine and 14C chlorella protein hydrolysate were used. Addition of the alcohol into incubation media caused the ethanol-dependent inhibition of sRNA aminoacylation by valine. leucine, proline, histidine as well as by amino acid mixture from the protein hydrolysate. At the same time, aminoacylation of sRNA by glycine and aspartic acid was unaltered. The rate of sRNA aminoacylation by aspartic acid was increased in presence of 85 mmole of ethanol.