RESUMEN
6 year molecular-biological monitoring of enteroviruses in the Far East and Zabaikalye was carried out. Nucleotide sequence of 125 strains was determined from 2006 to 2011. Molecular analysis was carried out in VP1 virus genome region. Phylogenetic interactions for ECHO-6, ECHO-30, ECHO-11, Coxsackie B-5 (CB-5), Coxsackie B-1 (CB-1) and Coxsackie A-9 (CA-9) were analyzed. Highly dynamic epidemiology was shown to be inherent for ECHO-6 and ECHO-30 viruses and is characterized by genetic heterogeneity and consequent change of virus variants. On the contrary a relative stability of circulating genotypes is intrinsic for CB-1, CB-5 and ECHO-11 enteroviruses. The results of molecular-biological studies indicate frequent introduction of new enterovirus variants from countries of Europe and Asia.
Asunto(s)
Infecciones por Enterovirus/epidemiología , Infecciones por Enterovirus/genética , Enterovirus/genética , Monitoreo Epidemiológico , Epidemiología Molecular , Infecciones por Enterovirus/transmisión , Femenino , Genotipo , Humanos , Masculino , Siberia/epidemiologíaAsunto(s)
Conjuntiva/parasitología , Dirofilaria repens/fisiología , Dirofilariasis/epidemiología , Párpados/parasitología , Adolescente , Adulto , Anciano , Animales , Conjuntiva/cirugía , Dirofilariasis/diagnóstico , Dirofilariasis/parasitología , Dirofilariasis/cirugía , Párpados/cirugía , Humanos , Masculino , Persona de Mediana Edad , Siberia/epidemiologíaRESUMEN
A total of 3194 cases of enterovirus meningitis were notified in the Russian Federation in 2005, of them there were 1434 cases in the Khabarovsk Territory. Enteroviruses were isolated from 1020 out of the virologically studied 1362 patients from the Khabarovsk Territory. Viruses E6 and E30 were isolated in 80 and 14.7% of cases, respectively. E1, E3, E7, E33, Coxsackie virus B1, B4, B5, and A10 were sporadically detected. The E6 strains isolated in Komsomolsk-on-Amur were identical while E6 strains isolated in Khabarovsk belonged to two different genotypes and greatly differed from those isolated in Konsomolsk-on-Amur. The virus E30 strains isolated in Khabarovsk and Komsomolsk-on-Amur had a 1% difference in VP1 genome nucleotide sequence and belonged to E30 subtype that circulated in Russia and Kazakhstan in 2004-2005.
Asunto(s)
Infecciones por Echovirus/epidemiología , Enterovirus Humano B/genética , Meningitis Aséptica/epidemiología , Epidemiología Molecular , Enterovirus Humano B/clasificación , Genoma Viral/genética , Humanos , Filogenia , Siberia/epidemiologíaRESUMEN
Results of epidemiologic, virologic, and serologic studies of enterovirus infections in Khabarovsk region from 1975 to 2006 were analyzed. Patterns of epidemic process of these infections were established: periodic change of dominating type of pathogen in the population; onset of the large epidemic peaks of incidence during emergence of circulation of new for the given area serotypes of enteroviruses; possibility of realization of several routes of virus transmission. Role of water factor in the progress of the epidemic process was revealed. Etiology of the large epidemic rise of aseptic meningitis incidence in Khabarovsk region in 2006 was established--the leading pathogens were ECHO viruses serotypes E6 and E30.