RESUMEN
The main epidemiological values characterizing rubella in Moscow were calculated on the basis of a new mathematical model. Quantitative estimates of the intensity of infection in different age groups of the population were obtained. It has been established that the risk of infection in children is especially high in comparison with adult population. That is why 98% of the population aged 15 are immune. The probability of falling ill with rubella was determined for persons with different antibody levels. The cases of congenital rubella in Moscow are rare due to the low risk of infection in adults and to their immunity acquired in childhood. Consequently, there is no necessity for vaccination against rubella in Moscow at the present time, but it should be recommended to organize constant epidemiological surveillance of congenital rubella.
Asunto(s)
Modelos Teóricos , Rubéola (Sarampión Alemán)/epidemiología , Adolescente , Adulto , Factores de Edad , Anticuerpos Antivirales/análisis , Niño , Preescolar , Femenino , Humanos , Lactante , Matemática , Persona de Mediana Edad , Moscú , Embarazo , Complicaciones Infecciosas del Embarazo/epidemiología , Complicaciones Infecciosas del Embarazo/inmunología , Rubéola (Sarampión Alemán)/congénito , Rubéola (Sarampión Alemán)/inmunología , Virus de la Rubéola/inmunologíaAsunto(s)
Brotes de Enfermedades/epidemiología , Gripe Humana/epidemiología , Femenino , Muerte Fetal/epidemiología , Muerte Fetal/etiología , Humanos , Lactante , Recién Nacido , Gripe Humana/complicaciones , Moscú , Complicaciones del Trabajo de Parto/epidemiología , Complicaciones del Trabajo de Parto/etiología , Embarazo , Complicaciones Infecciosas del Embarazo/epidemiología , Complicaciones Infecciosas del Embarazo/etiología , Población UrbanaRESUMEN
The results of combined clinico-virological and immunological examinations of 25 children with rubellar meningoencephalitis are presented. The meningoencephalitis was preceded by typical rubella in 24, and by rubellar infection without eruptions in 1 child. In 6 children the rubella virus was isolated from the cerebrospinal fluid in the acute period of the disease (5th to 19th days), and in 2 children it was re-isolated on the acute period of the disease (5th to 19th days), and in 2 children it was re-isolated on the 17th-19th days. A persistence of the immunoglobulins M specific to the rubella virus was revealed both in the acute period of the disease and long time after the disease onset (the observation period was 409 days). The data obtained confirm the etiological role of the rubella virus in the development of rubellar meningoencephalitis, suggesting that the rubella virus may persist in complicated post-natal rubella.
Asunto(s)
Meningoencefalitis/diagnóstico , Rubéola (Sarampión Alemán)/diagnóstico , Enfermedad Aguda , Adolescente , Anticuerpos Antivirales/análisis , Líquido Cefalorraquídeo/microbiología , Niño , Preescolar , Pruebas de Inhibición de Hemaglutinación , Humanos , Inmunoglobulina M/análisis , Lactante , Meningoencefalitis/microbiología , Rubéola (Sarampión Alemán)/microbiología , Virus de la Rubéola/aislamiento & purificaciónRESUMEN
The results of composite epidemiological, virological and morphological studies of intrauterine rubella infection performed in 1979, in the period of maximum increase of rubella incidence in Moscow for 11 years (1969-1979) are presented. Investigations of 125 foci of rubella established a relatively high frequency of contacts of pregnant women with the source of infection in families of rubella patients. Twenty-nine cases of clinically manifest and inapparent rubella among pregnant women were detected and confirmed in the laboratory; intrauterine infection at 3-17 weeks was established in 16 out of 18 virologically examined women. The ratio of the disease forms was 3.5 : 1. Using laboratory methods of investigations, rubella of pregnant women was confirmed in 100% cases. From the aborted and fetal materials collected in the disease or inapparent infections of pregnant women rubella virus was isolated in 88.9%, marked pathomorphological lesions were found in organs of 61% of the fetuses examined. The organotropism of rubella virus was confirmed by a high rate (87%) of virus isolation from placenta and umbilical cords as well as by localization of morphological lesions in these organs and in the eye lens tissues. These characteristics of marked teratogenic potentials of the circulating virus strains indicate the necessity of organization of regular epidemiological surveys of rubella in pregnant women for prevention of congenital rubella in the USSR.
Asunto(s)
Rubéola (Sarampión Alemán)/epidemiología , Animales , Anticuerpos Antivirales/análisis , Métodos Epidemiológicos , Femenino , Humanos , Moscú , Embarazo , Complicaciones Infecciosas del Embarazo/epidemiología , Complicaciones Infecciosas del Embarazo/microbiología , Complicaciones Infecciosas del Embarazo/patología , Conejos , Rubéola (Sarampión Alemán)/congénito , Rubéola (Sarampión Alemán)/microbiología , Rubéola (Sarampión Alemán)/patología , Virus de la Rubéola/inmunología , Virus de la Rubéola/aislamiento & purificaciónAsunto(s)
Anticuerpos Antivirales/análisis , Enfermedades del Sistema Nervioso Central/diagnóstico , Inmunoglobulina M/análisis , Virus del Sarampión/inmunología , Esclerosis Múltiple/diagnóstico , Adolescente , Adulto , Anciano , Diagnóstico Diferencial , Pruebas de Inhibición de Hemaglutinación , Pruebas de Hemaglutinación , Humanos , Persona de Mediana EdadRESUMEN
Seroepidemiological characteristics of rubella and cytomegalovirus infection in the north of the USSR were studied. Examinations of 21,000 patients with rubella and serological survey of 1500 subjects revealed the identity of the main epidemiological indices and age changes in antibody to rubella virus in the northern and central parts of the USSR. The general percentage of seropositives to cytomegalovirus is significantly higher in the north than in other parts of the country. The importance of the observed findings for the determination of the incidence of congenital pathology due to rubella and cytomegalovirus infection in the north is discussed.
Asunto(s)
Infecciones por Citomegalovirus/epidemiología , Rubéola (Sarampión Alemán)/epidemiología , Adolescente , Adulto , Factores de Edad , Anticuerpos Antivirales/análisis , Niño , Preescolar , Citomegalovirus/inmunología , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Rubéola (Sarampión Alemán)/inmunología , Virus de la Rubéola/inmunología , U.R.S.S.Asunto(s)
Anticuerpos Antivirales/análisis , Complejo Antígeno-Anticuerpo , Inmunoglobulina M/análisis , Inmunoadsorbentes , Virus de la Rubéola/inmunología , Rubéola (Sarampión Alemán)/diagnóstico , Staphylococcus aureus/inmunología , Adolescente , Adulto , Femenino , Pruebas de Inhibición de Hemaglutinación/métodos , Humanos , Recién Nacido , Intercambio Materno-Fetal , Embarazo , Complicaciones Infecciosas del Embarazo/diagnóstico , Rubéola (Sarampión Alemán)/congénitoRESUMEN
The possibility of using diploid cell strains derived from some organs and tissues of human embryo for isolation and propagation of rubella virus has been demonstrated. The marked cytopathic effect of the virus was followed in the time course and shown to be readily reproducible.