1.
Angew Chem Int Ed Engl
; 52(30): 7845-9, 2013 Jul 22.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23788484
RESUMEN
Palladium and CO: Carbonylation of 1 with [Pd(tfa)2(±)-L1] (tfa = trifluoroacetate) affords the spirofuranone 2 with inversion of the stereochemistry at C17 in 96 % yield. C17-epi-1 also gave the same product 2 with retention of the stereochemistry at C17. Labelling studies show that (13)CO was incorporated into the C5' position of the furanone ring. The first asymmetric version of this new reaction was achieved.