RESUMEN
Fusobacterium nucleatum is an invasive, adherent, and pro-inflammatory anaerobic bacterium involved in various infections and colorectal cancer. We report a case with pyogenic liver abscess, diagnosed with advanced sigmoid colon cancer, in whom F. nucleatum was simultaneously detected. In this patient, F. nucleatum was systematically analyzed using the molecular biological techniques of metagenome analysis, conventional PCR, and microbial fluorescence in situ hybridization.
Asunto(s)
Infecciones por Fusobacterium/diagnóstico , Infecciones por Fusobacterium/microbiología , Fusobacterium nucleatum/genética , Absceso Piógeno Hepático/diagnóstico , Absceso Piógeno Hepático/microbiología , Neoplasias del Colon Sigmoide/microbiología , Anciano , Biopsia , Fusobacterium nucleatum/clasificación , Humanos , Hibridación Fluorescente in Situ , Masculino , ARN Ribosómico 16S , Análisis de Secuencia de ADN , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
Plasma cell leukemia (PCL) is a rare variant of multiple myeloma (MM) with a poor prognosis. Nonsecretory myeloma is also a rare form of MM characterized by the absence of detectable M-protein in the serum and urine. This report describes two cases of nonsecretory PCL. The first patient was an 85-year-old man in whom the lack of monoclonal immunoglobulins made it difficult to make a diagnosis because the malignant cells showed an atypical morphology. He died of rapid disease progression before starting chemotherapy. The second patient was a 78-year-old woman whose tumor cells displayed a typical plasma cell morphology. She was successfully treated with bortezomib-containing chemotherapy.