RESUMEN
INTRODUCTION: The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. MATERIAL AND METHODS: Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. RESULTS: The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P<0.03) differences were found in comparison with the data on the healthy controls (E2, 6%; E3, 87%; E4, 8%). The apoE4 allele frequency was intermediate between HC and Alzheimer's dementia group (28%). CONCLUSION: These results indicate that the apoE4 allele could be a risk factor not only for certain primary degenerative, but also for vascular dementias.
Asunto(s)
Alelos , Apolipoproteínas E/genética , Demencia Vascular/genética , Frecuencia de los Genes/genética , Predisposición Genética a la Enfermedad/genética , Genética de Población , Anciano , Enfermedad de Alzheimer/diagnóstico , Enfermedad de Alzheimer/genética , Apolipoproteína E4 , Demencia por Múltiples Infartos/diagnóstico , Demencia por Múltiples Infartos/genética , Demencia Vascular/diagnóstico , Femenino , Genotipo , Humanos , Hungría , Masculino , Escala del Estado Mental , Reacción en Cadena de la Polimerasa , Factores de RiesgoAsunto(s)
Enfermedad de Alzheimer/fisiopatología , Antagonistas Colinérgicos/farmacología , Midriáticos/farmacología , Sistema Nervioso Parasimpático/efectos de los fármacos , Tropicamida/farmacología , Anciano , Anciano de 80 o más Años , Demencia Vascular/fisiopatología , Femenino , Humanos , Masculino , Sistema Nervioso Parasimpático/fisiopatología , Pupila/efectos de los fármacosRESUMEN
INTRODUCTION: The presence of the apolipoprotein E4 allele (apoE4) has been recognized as a risk factor for the development of presenile and senile forms of Alzheimer's dementia (AD). MATERIAL AND METHODS: The apoE alleles frequency of 71 normal controls (NC), 60 demented controls (DC) and 50 senile type AD subjects was determined by polymerase chain reaction in order to get data about the apoE polymorphism of the Hungarian AD population. RESULTS: The apoE3/3 genotype was the most common in all groups. The apoE4 frequency was significantly higher (28%) in the AD group than that was (7% and 9%) in the NC and DC populations, respectively. No apoE4 homozygotes were found in the DC group and the number of heterozygotes was lower in the DC than in the AD group. CONCLUSION: The results are in good agreement with others in the literature and support the occurrence of an increased apoE4 allele frequency in Hungarian senile AD population.