RESUMEN
The authors investigated the relationship between esophageal pressure fluctuation (DPes) during sleep and the following parameters: respiratory disorder variables and daytime sleepiness manifested as the Epworth sleepiness scale (ESS). In the younger patient group under 60 years of age (n=33), DPes was correlative to both the apnea-hypopnea index and ESS. However, in the elderly group of 60 years and over (n = 16), the variables showed smaller values than did those in the younger group. These results suggest that DPes may be associated with the aggravating process of sleep apnea syndrome (SAS) in the younger patient.
Asunto(s)
Resistencia de las Vías Respiratorias/fisiología , Esófago/fisiopatología , Apnea Obstructiva del Sueño/fisiopatología , Adulto , Factores de Edad , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polisomnografía , Apnea Obstructiva del Sueño/diagnósticoRESUMEN
We evaluated usefulness of dopamine administration after transcatheter hepatic arterial embolization (TAE) for the prevention of hepatic failure in experimental and clinical study. In experimental study we measured portal blood flow in dogs with doppler catheter before and after TAE. Administration of dopamine after TAE increased portal blood flow significantly. In a clinical study the usefulness of dopamine was investigated in a clinical laboratory test. It revealed that serum GOT and GPT improved earlier with dopamine administration after TAE. In conclusion dopamine increased portal blood flow and decreased hepatic parenchymal damage after TAE.
Asunto(s)
Dopamina/uso terapéutico , Embolización Terapéutica/efectos adversos , Arteria Hepática , Hepatopatías/prevención & control , Sistema Porta/efectos de los fármacos , Animales , Perros , Hemodinámica/efectos de los fármacos , Hemodinámica/fisiología , Humanos , Hepatopatías/etiología , Sistema Porta/fisiopatologíaRESUMEN
The enterohepatic circulation of cefixime in rat was evaluated by a nonlinear least square analysis program, MULTI(FILT), into which the fast inverse Laplace transform (FILT) was incorporated. The plasma time course in the bile duct-cannulated rat exhibited a biexponential curve after the rapid iv administration of cefixime. Several pharmacokinetic models for the enterohepatic circulation were constructed based on the recirculatory concept and the Laplace-transformed equations corresponding to these models were derived by means of the method of transfer function. The transformed equations were simultaneously fitted to the time courses of plasma concentration in rats with laparotomy and with bile duct cannula. The optimum model was selected based on the Akaike's information criterion (AIC). The local moment characteristics for a single pass through enterohepatic circulation were further calculated from the time courses of both the plasma concentration and the amount excreted into the bile. The recovery ratio (Fc) and the mean circulatory time (-tc) through a single pass of enterohepatic circulation were estimated 27.9% and 1.07 hr, respectively. The recovery ratio (Fa) and the mean absorption time (-tc) for the absorption process from the intestinal tract into the systemic circulation were 68.3% and 0.0234 hr, respectively. The recovery ratio (Fb) and the mean transit time (-tb) for the disposition process through the systemic circulation into the bile were 40.8% and 1.05 hr, respectively.
Asunto(s)
Cefotaxima/análogos & derivados , Circulación Enterohepática , Hígado/metabolismo , Animales , Disponibilidad Biológica , Cefixima , Cefotaxima/farmacocinética , Cromatografía Líquida de Alta Presión , Indicadores y Reactivos , Masculino , Matemática , Modelos Biológicos , Ratas , Ratas Endogámicas , Espectrofotometría UltravioletaRESUMEN
Changes in somatosensory evoked potentials (SEPs) over the non-affected hemisphere in 61 patients with unilateral cerebrovascular lesions were studied using age-matched controls. The latencies showed no significant differences when compared to controls. In cerebral infarctions produced by occlusion of the perforating artery in the middle cerebral artery (MCA), the amplitudes over the non-affected hemisphere decreased in the acute phases, but did not change in the chronic phases in comparison with the controls; whereas in cerebral infarctions produced by occlusion of the cortical artery in the MCA, the amplitudes over the non-affected hemisphere increased in the chronic phases compared to controls. The amplitudes over the non-affected hemisphere in intracerebral hemorrhages (ICH) increased in the chronic phases in comparison with the controls, but in the acute phases, they showed no change in the cortical artery group nor in ICH. The increases in the amplitudes were more prominent in patients with than in patients without sensory impairment. These data suggest that the affected hemisphere gives rise to high amplitude SEPs over the non-affected hemisphere.