RESUMEN
BACKGROUND: Cytomegalovirus (CMV) is a common virus. In pregnant women, CMV infection is usually mildly symptomatic or asymptomatic but can lead to fetal infection. Here we present a rare case of severe CMV pneumonitis and acute respiratory distress syndrome in a healthy immunocompetent pregnant woman. CASE PRESENTATION: A previous healthy 28-year-old woman with spontaneous conception, was admitted to the General University Hospital of Patras at 29 weeks of gestation with a day history of fever, fatigue, pharyngitis, and cough. She was diagnosed with acute CMV infection and CMV pneumonitis. During her hospitalization she developed acute distress syndrome (ARDS). The patient was intubated and underwent emergency caesarean delivery. She was admitted to the intensive care unit and received intravenous ganciclovir. She was discharged at 20th day postpartum in a good clinical condition. CONCLUSIONS: This case highlights the infrequent yet potential complexity of CMV infection in immunocompetent patients and in pregnancy.
Asunto(s)
Infecciones por Citomegalovirus , Neumonía , Síndrome de Dificultad Respiratoria , Humanos , Femenino , Embarazo , Adulto , Mujeres Embarazadas , Infecciones por Citomegalovirus/complicaciones , Infecciones por Citomegalovirus/diagnóstico , Infecciones por Citomegalovirus/tratamiento farmacológico , Ganciclovir/uso terapéutico , Citomegalovirus , Neumonía/complicaciones , Neumonía/diagnóstico , Neumonía/tratamiento farmacológico , Síndrome de Dificultad Respiratoria/diagnóstico , Síndrome de Dificultad Respiratoria/etiología , Síndrome de Dificultad Respiratoria/tratamiento farmacológicoRESUMEN
BACKGROUND: Demystifying the events around early pregnancy is challenging. A wide network of mediators and signaling cascades orchestrate the processes of implantation and trophoblast proliferation. Dysregulation of these pathways could be implicated in early pregnancy loss. There is accumulating evidence around the role of Wnt pathway in implantation and early pregnancy. The purpose of this study was to explore alterations in the expression of Wnt4, Wnt6 and ß-catenin in placental tissue obtained from human first trimester euploid miscarriages versus normally developing early pregnancies. METHODS: The study group consisted of first trimester miscarriages (early embryonic demises and incomplete miscarriages) and the control group of social terminations of pregnancy (TOPs). The placental mRNA expression of Wnt4, Wnt6 and ß-catenin was studied using reverse transcription PCR and real time PCR. Only euploid conceptions were included in the analysis. RESULTS: Wnt4 expression was significantly increased in placental tissue from first trimester miscarriages versus controls (p = 0.003). No significant difference was documented in the expression of Wnt6 (p = 0.286) and ß-catenin (p = 0.793). There was a 5.1fold increase in Wnt4 expression for early embryonic demises versus TOPs and a 7.6fold increase for incomplete miscarriages versus TOPs - no significant difference between the two subgroups of miscarriage (p = 0.533). CONCLUSIONS: This is, to our knowledge, the first study demonstrating significant alteration of Wnt4 expression in human placental tissue, from failed early pregnancies compared to normal controls. Undoubtedly, a more profound study is needed to confirm these preliminary findings and explore Wnt mediators as potential targets for strategies to predict and prevent miscarriage.
Asunto(s)
Aborto Espontáneo/genética , Placenta/metabolismo , Primer Trimestre del Embarazo/genética , Proteínas Wnt/genética , Proteína Wnt4/genética , beta Catenina/genética , Adulto , Proliferación Celular/genética , Femenino , Regulación del Desarrollo de la Expresión Génica , Humanos , Proyectos Piloto , Embarazo , Trofoblastos/citología , Trofoblastos/metabolismo , Vía de Señalización Wnt/genéticaRESUMEN
A 60-year-old healthy woman presented with fever, abdominal pain and bloody diarrhea. After initial conservative therapy, enterectomy was performed because of perforation of the jejunum. Histological analysis and high titer of anti-CMV IgM confirmed the diagnosis. A 2-year follow-up was uneventful. CMV enterocolitis is frequent in immunocompromised patients, but rare in immunocompetent subjects.