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Artículo en Ruso | MEDLINE | ID: mdl-2145719

RESUMEN

Antibodies to Bacillus anthracis protective antigen (PA) and to the lethal factor (LF) of B. anthracis exotoxin in the blood sera of anthrax patients and of subjects with a history of the disease, as well as of persons immunized with STI live vaccine, were studied by the heterogeneous enzyme immunoassay. In 1-6 years after convalescence the levels of anti-PA and anti-LF antibodies (at 75% and 96% detection rates respectively) were higher than on weeks 1-4 from the onset of the disease. In persons having had anthrax antibodies belonged mainly to IgG, and the anti-LF antibody level was higher than the anti-PA antibody level. In persons immunized with STI vaccine the detection rate of antibodies somewhat increased in 2-7 months after immunization, reaching, on the average, 72%, the antibody levels after primary immunization and regular annual booster immunization being similar. In 1-2 years after primary (booster) immunization the isolation rate of antibodies decreases to 21%. Specific features of postinfectious and postvaccinal immunity to anthrax and problems of retrospective diagnosis of this disease are discussed.


Asunto(s)
Carbunco/inmunología , Bacillus anthracis/inmunología , Vacunas Bacterianas/inmunología , Adulto , Enfermedades de los Trabajadores Agrícolas/diagnóstico , Enfermedades de los Trabajadores Agrícolas/inmunología , Enfermedades de los Trabajadores Agrícolas/prevención & control , Carbunco/diagnóstico , Carbunco/prevención & control , Anticuerpos Antibacterianos/sangre , Humanos , Inmunización , Inmunización Secundaria , Kazajstán , Persona de Mediana Edad , Recurrencia , Estudios Retrospectivos , Factores de Tiempo
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