RESUMEN

We compared very high doses of methylprednisolone with intravenously administered immune globulin for treatment of acute idiopathic thrombocytopenic purpura. Fifty-seven children were randomly assigned to receive the immune globulin preparation, 0.5 gm/kg per day for 5 consecutive days (n = 19), orally administered methylprednisolone, 30 mg/kg per day for 7 days (n = 19), or orally administered methylprednisolone, 50 mg/kg per day for 7 days (n = 19). There were no differences in the response of the platelet counts among the groups. We conclude that these two therapies were equally effective; choice between them may be made according to cost and therapy-related risks.

Asunto(s)

Inmunoglobulinas Intravenosas/administración & dosificación , Metilprednisolona/administración & dosificación , Púrpura Trombocitopénica Idiopática/terapia , Enfermedad Aguda , Administración Oral , Adolescente , Análisis de Varianza , Niño , Preescolar , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Femenino , Estudios de Seguimiento , Humanos , Inmunoglobulinas Intravenosas/farmacología , Inmunoglobulinas Intravenosas/uso terapéutico , Lactante , Masculino , Metilprednisolona/farmacología , Metilprednisolona/uso terapéutico , Recuento de Plaquetas/efectos de los fármacos , Púrpura Trombocitopénica Idiopática/sangre