RESUMEN
There are two strategies for scheduling personal goals: (i) clock-time, based on time passage; and (ii) event-time, based on the progress made. Neither strategy is always superior to the other; rather it is necessary to consider the environment and other conditions such as whether the goal is long or short term. We focused on goal lengthas an important factor for determining the best scheduling strategy, hypothesizing that clock-time and event-time strategies would differentially activate higher performance for long-term and short-term goals, respectively. Thus, we conducted a two-part laboratory experiment (Part 1: n = 63, Part 2: n = 86 ) in which we manipulated both goal length and scheduling strategy. Subsequently, we examined the effects of each combination of goal length and scheduling strategy on task performance (i.e., completion of a mathematical problem). Although our two studies were designed identically in most respects, they differed in the number of task problems, task time limits, and question content. Our data supported our hypothesis that clock-time scheduling was optimal for long-term goals while event-time scheduling was optimal for short-term goals.
Asunto(s)
Objetivos , Motivación , Humanos , Logro , Pensamiento , Factores de TiempoRESUMEN
Dietary or caloric restriction confers various clinical benefits. Short-term fasting of mice is a common experimental procedure that may involve systemic metabolic remodeling, which may significantly affect experimental outputs. This study evaluated adaptive cellular responses after 1- or 2-day fasting in 13 mouse tissues by quantitative PCR using 15 marker primer sets for the activation of ubiquitin-proteasome (Atrogin-1 and MuRF1), autophagy-lysosome (LC3b, p62 and Lamp2), amino acid response (Asns, Trib3, Herpud1, xCT, and Chop), Nrf2-mediated antioxidant (HO-1 and Gsta1), and amino acid transport (Slc38a2, Slc7a5, and Slc7a1) systems. Differential activation profiles obtained in seven highly (thymus, liver, spleen, and small intestine) or mildly (stomach, kidney, and colon) atrophied tissues as well as in six non-atrophied tissues (brain, eye, lung, heart, skeletal muscle, and testis) suggested tissue-specific active metabolic remodeling.