RESUMEN
INTRODUCTION: Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms. Surgery is the only curative treatment option. However, our understanding of predictors of survival after surgery remains incomplete. The aim of the study was to evaluate metabolic syndrome (MetS) as a prognostic factor in pNET. METHODS: In a retrospective single-center cohort study, we examined the influence of MetS in 120 patients with curative intended resection of pNETs on overall survival (OS), recurrence-free survival, and outcome after recurrence. RESULTS: MetS was present in 32 patients (26.6%). Patients with MetS had an impaired OS after curative intended surgery compared to patients without MetS (median OS 72 months [95% CI 13.3-130.7] vs. not reached, p < 0.001). The shortest survival was observed in patients with MetS in the presence of oligometastatic disease at time of surgery. In a multivariable Cox regression analysis, MetS was identified as an independent risk factor for mortality (hazard ratio [HR] = 4.54, 95% CI [1.88-11.00], p = 0.01). In our dataset, MetS was not associated with tumor recurrence or recurrence-free survival. Nevertheless, in patients with recurrence, MetS was associated with shorter time to recurrence (median 3.4 months, 95% CI [2.48-4.24], vs. 20.1 months, 95% CI [10.8-29.49], p < 0.001), and poor outcome (HR = 5.03, 95% CI [1.25-20.20], p = 0.01). CONCLUSIONS: We identified MetS as a negative prognostic factor after curative intended surgery for pNET. In particular, patients with oligometastatic disease might not benefit from extensive surgery in the presence of MetS. Furthermore, MetS had a strong impact on survival after recurrence.
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Síndrome Metabólico , Tumores Neuroectodérmicos Primitivos , Tumores Neuroendocrinos , Neoplasias Pancreáticas , Humanos , Tumores Neuroendocrinos/complicaciones , Tumores Neuroendocrinos/cirugía , Neoplasias Pancreáticas/complicaciones , Neoplasias Pancreáticas/cirugía , Estudios Retrospectivos , Síndrome Metabólico/complicaciones , Síndrome Metabólico/cirugía , Estudios de Cohortes , PronósticoRESUMEN
BACKGROUND: Infants in the first 90 days of life are more prone to develop serious bacterial infections (SBIs). Multi-drug-resistant organisms (MDROs) are emerging as important pathogens causing SBIs. We reviewed the epidemiology of SBIs in infants 0-90 days old and compared the clinical features, laboratory values and final outcome for SBIs due to MDROs vs. non-MDROs. METHODS: Episodes of culture-proven SBIs (bacteremia, urinary tract infections, or meningitis) with age at onset of 0-90 days during a 7-year period were retrospectively reviewed. Health care-associated infections were excluded. We collected demographics, clinical features, and laboratory and microbiology data. We compared clinical characteristics, laboratory data, microbiologic results and final outcome for SBIs due to MDROs vs. non-MDROs. RESULTS: Ninety-four episodes (88 patients) including bacteremia (42.6%), urinary tract infections (54.3%) and meningitis (3.1%) were caused by Gram-negative bacteria (67%), and Gram-positive bacteria (33%). Escherichia coli, Klebsiella pneumoniae and GBS were the most common causes. MDROs caused SBIs in 39 patients (44.3%). SBIs due to MDROs were associated with more delay in providing targeted antimicrobial therapy compared to non-MDROs (74.4% vs. 0%, P ≤ 0.001), but no difference in case-fatality rate (12.8% vs. 12.2%, P = 1.0). Clinical features or basic laboratory values were not statistically different between the two groups. CONCLUSIONS: The bacteriology of SBIs in the first 90 days of life is changing to include more MDROs, which causes more delay in providing targeted antimicrobial therapy. Awareness of the local epidemiology is crucial to ensure appropriate antibiotics are provided in a timely manner.
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Bacteriemia/tratamiento farmacológico , Bacteriemia/microbiología , Meningitis Bacterianas/tratamiento farmacológico , Meningitis Bacterianas/microbiología , Infecciones Urinarias/tratamiento farmacológico , Infecciones Urinarias/microbiología , Factores de Edad , Infecciones Comunitarias Adquiridas/tratamiento farmacológico , Infecciones Comunitarias Adquiridas/microbiología , Farmacorresistencia Bacteriana Múltiple , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Estudios Retrospectivos , Índice de Severidad de la EnfermedadRESUMEN
BACKGROUND: Antimicrobial resistance represents a significant public health problem worldwide. Irrational use of antibiotics is the main driving factor for the evolution of antimicrobials-resistant organisms. The aim of this study is to evaluate the areas of defects in the knowledge and practices of the community about antibiotic use. METHODS: A cross-sectional study on a sample of 1060 randomly-selected adults residing in the North of Jordan using a pre-validated questionnaire to evaluate knowledge, practices and attitude toward antimicrobial use and misuse, as well as to assess knowledge about antimicrobial resistance. RESULTS: Of all respondents, 41% (n = 437) stated that they have received oral antibiotics in the past two months, of which 38% acquired the antibiotics without a prescription. 32% of those who received antibiotics did not complete the recommended course of treatment. 39-54% of the sample population believe in common misconceptions/malpractices of antibiotics use. The majority (70%) of the respondents have not known about the term "antimicrobials resistance". Although people with higher education and higher income were generally more knowledgeable about appropriate antibiotics use and antimicrobial resistance, responses to some of the most important aspects in the assessment of knowledge showed no statistical difference between the different groups. CONCLUSIONS: Our data revealed major defects in the public knowledge about appropriate antibiotics use, as well as lack of awareness on "antimicrobial resistance" problem. Awareness about appropriate antibiotic use and the serious consequences of antibiotic misuse should reach everyone in the community regardless of their educational or economic status.