RESUMEN
OBJECTIVE: Newborn infants, particularly preterm infants, are at greater risk of oxidative stress because of an imbalance between high oxidant loads and immature antioxidant defenses. In several studies, the activities of serum paraoxonase (PON) and arylesterase (ARE) have been found to decline in patients under increased oxidative stress. We investigated the relationships between PON-1 and ARE with fasting and postprandial in premature newborns in this study. PATIENTS AND METHODS: Serum paraoxonase-1 and arylesterase levels were investigated in premature infants less than 37 weeks, after birth while they were fasting and postprandial. RESULTS: The paraoxonase-1 and arylesterase values of infants in fasting were significantly lower than the values in postprandial (for paraoxonase-1, p = 0.034, 0.002, and 0.002, respectively; for arylesterase, p < 0.001, 0.002, and p < 0.001, respectively). CONCLUSIONS: In premature infants, paraoxonase-1 and arylesterase values are increased in postprandial and reduced in fasting, showing that these neonates are subjected to oxidative stress. Thus, starting feeding as soon as possible in premature newborns is vital to protect them from oxidative damage.
Asunto(s)
Antioxidantes/metabolismo , Arildialquilfosfatasa/sangre , Hidrolasas de Éster Carboxílico/sangre , Ayuno/sangre , Recien Nacido Prematuro/sangre , Periodo Posprandial/fisiología , Biomarcadores/sangre , Femenino , Humanos , Recién Nacido , Masculino , Estrés Oxidativo/fisiologíaRESUMEN
OBJECTIVE: Coeliac disease is a chronic disease and is common all over the world. It has many other associated systemic side effects. This study investigated the effect of paternal and maternal silent coeliac disease on birthweight and gestational age in newborns. METHODS: The study group consisted of 81 newborns who were hospitalized for prematurity or term-intrauterine growth retardation. The parents of premature and/or small for gestational age babies born with coeliac disease-specific antigens were investigated. RESULTS: The differences were not statistically significant in fathers' tissue transglutaminase levels between premature appropriate gestational age, premature small gestational age and term small gestational age infants (p > 0.05), but statistically significant in mothers (p < 0.05). CONCLUSIONS: Silent coeliac disease may occur in parents, especially in mothers of preterm and small for gestational age infants, even in the absence of apparent clinical indications.
RESUMEN
The acrofacial dysostoses are a heterogeneous group of disorders characterised by defects in craniofacial and limb development. The hallmarks include downward slanting palpebral fissures, malar hypoplasia, and retrognathia combined with variable limb malformations. We report the patient, a 5-day-old-boy with craniofacial dysmorphic features and upper and lower limb defects respectively.
Asunto(s)
Anomalías Múltiples , Deformidades Congénitas de las Extremidades , Disostosis Mandibulofacial , Adulto , Femenino , Humanos , Recién Nacido , Deformidades Congénitas de las Extremidades/diagnóstico por imagen , Masculino , Radiografía , SíndromeRESUMEN
The Klippel-Feil deformity is a complex of osseous and visceral anomalies, which include low hairline, platybasia, fused cervical vertebrae with a short neck, and deafness. Associated central nervous system abnormalities include occipital cephalocele, Chiari I malformation, syrinx, microcephaly, and hydrocephalus. Herein, we report a case with Klippel-Feil syndrome and Dandy-Walker malformation.
Asunto(s)
Vértebras Cervicales/anomalías , Síndrome de Dandy-Walker/diagnóstico , Síndrome de Klippel-Feil/diagnóstico , Vértebras Torácicas/anomalías , Encéfalo/patología , Síndrome de Dandy-Walker/genética , Resultado Fatal , Femenino , Humanos , Recién Nacido , Síndrome de Klippel-Feil/genética , Tomografía Computarizada por Rayos XRESUMEN
We report a male infant with fibular aplasia, tibial campomelia, and oligosyndactyly (FATCO syndrome). Radiographs showed a short angulated left tibia with fibular aplasia and ipsilateral oligodactyly. We consider our case the 7th patient with FATCO syndrome.