RESUMEN

Follicular lymphoma (FL) is one of the most common Non-Hodgkin lymphoma (NHL) subtype. Only small number of studies concerning NHL and DNA reparation gene polymorphisms has been performed so far. Hence, we have assessed the effect of 4 selected polymorphisms with possible influence on risk of FL development in a case-control study in Slovak population. We have genotyped polymorphisms in the RAG1 (K820R), LIG4 (T9I), BRCA2 (N372H), and WRN (V114I) genes in 108 patients with histologically proven FL diagnosis and 127 healthy controls. For discrimination between the allelic variants, we have established the genotyping by real-time melting analysis of an unlabeled probe. The most notable finding was related to polymorphism N372H in the BRCA2 gene. Compared with the wild-type genotype (NN), the homozygous variant genotype (HH) was associated with an increased FL risk (OR = 2.91, 95% CI: 0.96-8.81), although on the borderline of statistical significance (P = 0.050). However, after stratification by gender and age, the FL risk was significantly increased in men with variant-containing genotypes (OR = 2.79, 95% CI: 1.20-6.45) and even severalfold significantly increased among men with homozygous variant BRCA2 genotype (OR = 21.18, 95% CI: 2.46-182.2). No significant associations with FL risk were identified for other polymorphisms.

Asunto(s)

Proteína BRCA2/genética , Predisposición Genética a la Enfermedad , Linfoma Folicular/epidemiología , Linfoma Folicular/genética , Polimorfismo de Nucleótido Simple/genética , Adulto , Anciano , Anciano de 80 o más Años , Alelos , Estudios de Casos y Controles , ADN/genética , ADN Ligasa (ATP) , ADN Ligasas/genética , Exodesoxirribonucleasas/genética , Femenino , Genotipo , Proteínas de Homeodominio/genética , Humanos , Linfoma Folicular/patología , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Pronóstico , RecQ Helicasas/genética , Factores de Riesgo , Eslovaquia/epidemiología , Helicasa del Síndrome de Werner , Adulto Joven