RESUMEN
The aim of this study is to fabricate a highly porous scaffold based on gelatin/sodium alginate/45S5 bioglass with improved mechanical strength. Glycidoxypropyltrimethoxysilane (GPTMS) is used as a cross-linker and for the first time a nonionic bio-surfactant (Tween 80) is introduced to the composition to evaluate whether the essential properties of a suitable scaffold for bone substitution can be reached or not. The composite scaffolds are prepared through freeze-drying of suspension containing various ratios of gelatin/sodium alginate/45S5 bioglass. Characterization of fabricated scaffolds is carried out. SEM micrographs reveal that all samples are highly porous however incorporation of 1% v/v tween 80 results in well-shaped pores, with sizes ranging between 100 and 200 µm which is appropriate for tissue regeneration. Compressive strength of foamed scaffolds in contact with body solution has been enhanced from 0.37 to 1.41 MPa due to addition of tween 80. Foamed scaffold reinforced with tween 80 maintained its structural stability within 7 days immersion in simulated body fluid (SBF) despite the absorption of water 15 times its weight. Moreover, in vitro calcium phosphate precipitation is well observed on the surface of scaffolds.
Asunto(s)
Alginatos/química , Huesos/citología , Cerámica/química , Gelatina/química , Polisorbatos/química , Silanos/química , Andamios del Tejido/química , Materiales Biocompatibles/química , Materiales Biocompatibles/farmacología , Fenómenos Mecánicos , Porosidad , Tensoactivos/química , Ingeniería de TejidosRESUMEN
SnS:In thin films were grown on fluorine doped tin oxide (FTO) substrate by cathodic electrodeposition technique. The solution was containing 2mM SnCl2 and 16mM Na2S2O3 and different amounts of 1mM InCl3 as In-dopant. The pH, bath temperature, deposition time, and deposition potential (E) were fixed at 2.1, 60°C, 30min, and -1V, respectively. The XRD results showed that the synthesized films were polycrystalline orthorhombic SnS. The XPS results demonstrated that the films were composed of Sn, S and In. According to the FESEM images, an increase in In-dopant concentration leads to a change in morphology from grain-like to sheet-like having a nanoscale thickness of 20-80nm and fiber-like. The PL spectra of undoped SnS exhibited four emission peaks including a UV peak, two blue emission peaks, and an IR emission peak. According to the UV-Vis spectra, the direct band gap of SnS:In thin films was estimated to be 1.40-1.66eV.