RESUMEN
The effect of lithonite and piracetam on the cardiac rhythm, dynamics of infarction, metabolism, and immunological reactivity of the animals' organism was studied in dogs with experimental myocardial infarction. The pharmacotherapeutic activity of lithonite was found to be higher than that of piracetam.
Asunto(s)
Infarto del Miocardio/tratamiento farmacológico , Ácidos Nicotínicos/uso terapéutico , Piracetam/uso terapéutico , Animales , Constricción , PerrosRESUMEN
The effect of piracetam on the dynamics of the infarction development, free radical lipid peroxidation in the myocardium and the immunological reactivity was studied on dogs with experimental myocardial infarction during the course and prophylactic treatment. The antiarrhythmic, antihypoxic, antioxidant effects of the drug, its positive influence on the parameters of humoral and cellular immunity were revealed. The comparative assessment of piracetam action during cardiogenic stress caused by myocardial infarction showed a higher pharmacological effect in therapeutic use.
Asunto(s)
Infarto del Miocardio/prevención & control , Piracetam/uso terapéutico , Pirrolidinonas/uso terapéutico , Animales , Modelos Animales de Enfermedad , Perros , Evaluación Preclínica de Medicamentos , Infarto del Miocardio/tratamiento farmacológico , Infarto del Miocardio/inmunología , Choque Cardiogénico/tratamiento farmacológico , Choque Cardiogénico/inmunología , Choque Cardiogénico/prevención & control , Linfocitos T/efectos de los fármacos , Linfocitos T/inmunología , Factores de TiempoRESUMEN
Influence of litonit and piracetam on development of experimental myocardial infarction, free radical lipid oxidation in myocardium and immunological reactivity was studied in dogs. The analysis of pharmacological action of litonit and piracetam in cardiogenic stress proves more positive effect of litonit upon dynamics of myocardial infarction, peroxide lipid oxidation process, humoral and cellular immunity indexes.
Asunto(s)
Infarto del Miocardio/tratamiento farmacológico , Ácidos Nicotínicos/uso terapéutico , Piracetam/uso terapéutico , Pirrolidinonas/uso terapéutico , Tranquilizantes/uso terapéutico , Animales , Perros , Peroxidación de Lípido , Infarto del Miocardio/inmunología , Infarto del Miocardio/metabolismo , Miocardio/metabolismoRESUMEN
The influence of cyclophosphamide immunodepressants and 6-mercaptopurine on the electrocardiogram shifts, myocardial metabolism and humoral and cellular immunity indices has been studied on the dogs with experimental infarction. The results of the investigation show the incongruity to use cyclophosphamide immunodepressants and 6-mercaptopurine under myocardial infarction as they inhibit immunological reactivity, deteriorate coronary circulation and myocardial metabolism as well as retard reparative processes in the cardiac muscle.