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The feasibility of using molecular genetic markers associated with thyroid neoplasms and more aggressive course of the disease is now actively studied. We analyzed the diagnostic value of somatic mutations in the hot spots of BRAF, KRAS, KRAS, EIF1AX, and TERT genes in histological material from 153 patients with thyroid gland neoplasms. BRAF mutations (exon 15, codon area 600-601) were found in 54 patients, NRAS mutations (exon 3, codon 61) were detected in 12 patients; mutations KRAS, TERT, and EIF1AX genes were not detected.

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Codón/genética , Factor 1 Eucariótico de Iniciación/genética , Exones/genética , GTP Fosfohidrolasas/genética , Proteínas de la Membrana/genética , Mutación/genética , Proteínas Proto-Oncogénicas p21(ras)/genética , Telomerasa/genética , Neoplasias de la Tiroides/genética , Neoplasias de la Tiroides/patología , Humanos , Proteínas Proto-Oncogénicas B-raf/genética

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