RESUMEN

In vivo binding of a benzodiazepine (flunitrazepam-C11) and a benzodiazepine antagonist (Ro 15-1788-C11) were studied with positron emission tomography. Advantages and disadvantages of each drug for studying specific in vivo binding sites are presented. The results obtained indicate that Ro 15-1788-C11 is a better in vivo radiocoordinat than flunitrazepam-C11.

Asunto(s)

Ansiolíticos/metabolismo , Benzodiazepinas/metabolismo , Benzodiazepinonas/metabolismo , Flunitrazepam/metabolismo , Receptores de Superficie Celular/metabolismo , Animales , Benzodiazepinas/antagonistas & inhibidores , Unión Competitiva , Encéfalo/metabolismo , Flumazenil , Cinética , Papio , Receptores de GABA-A , Tomografía Computarizada de Emisión/métodos