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Maturitas ; 6(4): 359-67, 1984 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-6543461

RESUMEN

The vaginal absorption of micronized oestradiol/progesterone from a hydrophilic matrix system was investigated before and after 10 days of treatment in 7 post-menopausal women with an average age of 56.1 yr. Oestradiol and progesterone levels were measured on days 1 and 11 before administration and 0.5, 1, 2, 3, 4, 6, 8, 12, and 24 h afterwards by radioimmunoassay. Peak values were seen 6-12 h after administration. This finding differs from those of other investigations. Sex hormone binding globulin (SHBG) and androgen concentrations were unchanged after 10 days of treatment.


Asunto(s)
Estradiol/metabolismo , Progesterona/metabolismo , Vagina/metabolismo , Andrógenos/sangre , Estradiol/administración & dosificación , Femenino , Humanos , Menopausia , Persona de Mediana Edad , Progesterona/administración & dosificación , Globulina de Unión a Hormona Sexual/metabolismo , Supositorios , Factores de Tiempo
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