RESUMEN
Osteosarcoma (OS) is the most common primary bone tumour, with a peak incidence in adolescents, and the five-year survival rate of patients with metastasis or recurrence is much lower than that of patients without metastasis and recurrence. OS is initiated and develops in a complex tumour microenvironment (TME) that contains many different components, such as osteoblasts, osteoclasts, mesenchymal stem cells, fibroblasts, immune cells, extracellular matrix (ECM), extracellular vesicles, and cytokines. The extensive interaction between OS and the TME underlies OS progression. Therefore, rather than targeting OS cells, targeting the key factors in the TME may yield novel therapeutic approaches. MicroRNAs (miRNAs) play multiple roles in the biological behaviours of OS, and recent studies have implied that miRNAs are involved in mediating the communication between OS cells and the surrounding TME. Here, we review the TME landscape and the miRNA dysregulation of OS, describe the role of the altered TME in OS development and highlight the role of miRNA in the crosstalk between OS cells and the TME.
RESUMEN
Objective To understand the subjective perception and influential factors of critical care training in rescue nurses. Methods The same self-designed questionnaire with a total of 49 closing entries were used before and after training course to investigate the ability of critical care and prevention ability of infectious diseases in rescue nurses. Results The ability of emergency response nursing improved remarkably after rescue nurse training (t=-7.071--3.693,P thinking, the differences were statistically significant (t=-6.736--3.286,P<0.01). Conclusions Rescue nurses training can improve the ability to take care of critical illness under emergency situations, which can ease the insufficiency of human resource for short-term.
RESUMEN
Objective To explore the effects of QCC on reducing unqualified rate of blood specimens before analysis in emergency department. Methods Theme of QCC activity was decided according to the collected data in emergency de-partment from January to June 2014. QCC team was established, activity plan was initiated, and unqualified reasons before analysis of blood specimens were investigated. All rectification methods were implemented, and implementation effects were monitored through data collection from July to December 2014. Results Unqualified rate of blood speci-mens before analysis in emergency department was reduced to 1.32‰, and the difference was statistically significant compared with that of 5.91‰ before QCC (P<0.05); satisfaction rate of patients and family increased from 78.00% to 91.00%. Conclusion Application of QCC is able to effectively reduce unqualified rate of blood specimens before analysis in emergency department,improve patients' satisfaction,as well as enhance nurses' capabilities to solve clinical prob-lems by QCC.