RESUMEN
Ten arylsulfonylhydrazones were prepared from various heterocycles. The antimicrobial activity of these compounds was investigated, as was the cytotoxic activity of one of them.
Asunto(s)
Hidrazonas/síntesis química , Animales , Antibacterianos/síntesis química , Antineoplásicos/síntesis química , Fenómenos Químicos , Química , Escherichia coli/efectos de los fármacos , Hidrazonas/farmacología , Métodos , Ratones , Staphylococcus aureus/efectos de los fármacosRESUMEN
The preparation of the quaternary acetate and propionate esters of 3-hydroxyquinolizidine is described. Tentative structures are assigned on the basis of NMR data. Results of preliminary pharmacological screening of the methiodide and hydrochloride salts are given.
Asunto(s)
Quinolizinas/síntesis química , Acetilcolina/antagonistas & inhibidores , Acetilcolina/farmacología , Animales , Atropina/farmacología , Técnicas In Vitro , Yeyuno/efectos de los fármacos , Métodos , Contracción Muscular/efectos de los fármacos , Músculo Liso/efectos de los fármacos , Parasimpaticomiméticos/antagonistas & inhibidores , Parasimpaticomiméticos/síntesis química , Quinolizinas/antagonistas & inhibidores , Quinolizinas/farmacología , RatasRESUMEN
A method for assay of the ferrous ion in hematinics or multivitamin tablets is described. The method is based on the spectrophotometric measurement of the chromophore produced by reacting the ferrous ion with the highly specific chelating agent ferrozine. The method is proposed as an alternative to the redox methods in the USP and NF.
Asunto(s)
Compuestos Ferrosos/análisis , Hierro/análisis , Métodos , Espectrofotometría , ComprimidosRESUMEN
Magnolidin, the major glycoside of Magnolia grandiflora L. consists of two moles of rhamnose, and each of glucose, caffeic acid and 3,4-dihydroxyphenethanol. Based on degradative and spectroscopic evidence, a structure is proposed for magnolidin as one of two possible alternatives which differ with respect to the position occupied by the O-caffeyl unit.