RESUMEN

It is known that cAMP and cGMP, as an "intracellular second messenger system" play a significant role as a signal system, in the mechanism of action of anti-ulcerogenic (cytoprotective) drugs. According to our present, preliminary investigations it seems that during different experimental circumstances the gastric mucosal 3'-5'-cyclic-cytidine-mono-phosphate (cCMP) 3'-5'-cyclic-uridine-monophosphate and (cUMP) levels were changed--similarly to CAMP and cGMP--and these changes might be a possible indicator of a further, most probably secondary, signal- system role.

Asunto(s)

Mucosa Gástrica/fisiología , Membranas Intracelulares/fisiología , Transducción de Señal/fisiología , Animales , AMP Cíclico/metabolismo , CMP Cíclico/metabolismo , GMP Cíclico/metabolismo , Dinoprostona/farmacología , Epoprostenol/farmacología , Femenino , Mucosa Gástrica/efectos de los fármacos , Antagonistas de los Receptores H2 de la Histamina/farmacología , Nucleótidos Cíclicos/metabolismo , Ranitidina/farmacología , Ratas , Ratas Wistar , Uridina Monofosfato/metabolismo