RESUMEN

Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of alphabeta T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4(+) T cells was necessary to prevent lethal encephalitis in mice lacking alphabeta T cell receptor.

Asunto(s)

Linfocitos T CD4-Positivos/inmunología , Virus de la Encefalitis Equina Venezolana/inmunología , Encefalomielitis Equina Venezolana/inmunología , Traslado Adoptivo , Animales , Anticuerpos Antivirales/administración & dosificación , Anticuerpos Antivirales/inmunología , Encefalomielitis Equina Venezolana/prevención & control , Femenino , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Pruebas de Neutralización , Receptores de Antígenos de Linfocitos T/deficiencia , Análisis de Supervivencia