RESUMEN

Objective To explore the correlation between platelet endothelial aggregation receptor-1(PEAR1)gene polymorphisms and vascular access infections in intermittent hemodialysis(IHD)patients.Methods Totally 105 patients who received IHD treatment in Shaanxi Provincial People's Hospital from January 2019 to January 2022 were selected as the obser-vation group,and 50 healthy people who were admitted to the hospital for physical examination at the same period were selected as the control group,and PEAR1 gene polymorphisms of the subjects in the two groups were tested by polymerase chain reaction.In addition,the patients in the observation group underwent imaging,serology,and pathogenesis,and they were divided into infected group and uninfected group according to whether vascular access infections occurred,and the clinical data of patients between the two groups were compared,and the correlation between PEAR1 gene polymorphisms and vascular access infections in IHD patients was analyzed by using univariate and multifactorial logsitic regression.Results There were two alleles G and A at the PEAR1 gene locus of patients in the observation group and control group;and three genotypes were detected,including wild-type(GG),mutant heterozygous(GA),and mutant pure(AA).The frequency of the GG genotype and the frequency of the G allele genotype of the patients in the observation group were higher than those in the control group(P＜0.05);the allele frequencies of the gene loci of the subjects in the observation group and the control group were in accordance with the Hardy-Weinberg equilibrium(P＞0.05).Univariate analysis showed that there was no statistically significant difference in the sex ratio,body temperature,body mass index,blood pressure,triglyceride,total cholesterol,low-density lipoprotein,high-density lipoprotein,frequency of the GA and AA genotypes,percentage of history of hyperlipidemia,percentage of history of cigarette smoking,and percentage of history of alcohol consumption of patients between the infected group and uninfected group(P＞0.05).The age the percentage of dialysis duration＞3 years,the percentage of dialysis frequency ≥3 times in 1 week,the frequency of PEAR1 GG genotype,the frequency of PEAR1 G allele,the troponin T level,leukocyte level,platelet count level,hematocrit level,procalcitonin level,neutrophil/lymphocyte ratio,platelet/lymphocyte ratio,hypertension history and diabetes history of patients in the uninfected group were all lower than those in the infected group,while the fre-quency of PEAR1 A allele was higher than that in the infected group(P＜0.05).Logistic regression analysis showed that long dialysis duration,older age and high dialysis frequency,high neutrophil/lymphocyte ratio,high platelet/lymphocyte ratio,and PE AR1 G allele were risk factors for developing vascular access infections in patients with IHD(P＜0.05).Conclusion IHD patients have PEAR1 genotype expression abnormality,in which the risk of vascular access infection in patients with PEAR1 genotype GG is higher,which can be used as an effective factor for the early prediction of vascular access infection in hemodialysis patients.