RESUMEN
The present study was undertaken with purpose to investigate the relationships between intraepithelial proliferations of malpighian mucosa and the presence of group specific papilloma virus antigens. The investigations allowing to give viral types or subtypes, the hybridization technics, are very heavy and not disponible in routine practice. The detection of widely distributed genus specific HPV antigen using PAP immunohistochemical labeling in different lesions and their association with displastic or neoplastic processes is presented. Only few studies were performed on oral mucosal proliferations, showing the association of these viral proteins with papillomatous or condylomatous lesions. Our work is directed towards the identification of the HPV antigens in more advanced lesions and in the mucosal epithelium surrounding and perhaps preexistent with the buccal cancer.
Asunto(s)
Antígenos Virales/análisis , Mucosa Bucal/inmunología , Papillomaviridae/inmunología , Infecciones Tumorales por Virus/inmunología , Adulto , Anciano , Animales , Papillomavirus Bovino 1/inmunología , Transformación Celular Neoplásica , Niño , Condiloma Acuminado/inmunología , ADN Viral/aislamiento & purificación , Epítopos , Neoplasias de los Genitales Masculinos/inmunología , Humanos , Técnicas para Inmunoenzimas , Masculino , Neoplasias de la Boca/inmunología , Hibridación de Ácido Nucleico , Papillomaviridae/patogenicidad , Lesiones Precancerosas/inmunología , Conejos , Proteínas Virales/análisis , Virión/ultraestructuraRESUMEN
Fractures of the frontal sinus are frequently seen in patients with cranio-facial injuries. Trauma to the posterior wall and more deeply located tissues: anterior fossa, dura and brain, give an indication of the seriousness of such injuries. We point out some particular aspects of our experience; in the neurosurgical approach to such lesions; we use a classification based on treatment: -when the posterior wall of the sinus is not, or only slightly damaged, we drain it using a thin suction catheter pulled through the fronto-nasal duct, kept in place for six to ten days. -when a comminuted fracture of the frontal arch occurs in the sinus area, a large cortico-cancellous onlay bone graft is used to rebuild a harmonious frontal contour and avoid the risk of secondary deformity.
Asunto(s)
Fracturas Óseas/cirugía , Hueso Frontal/lesiones , Seno Frontal/lesiones , Adolescente , Adulto , Anciano , Niño , Femenino , Fracturas Óseas/clasificación , Fracturas Óseas/complicaciones , Hueso Frontal/cirugía , Seno Frontal/cirugía , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The authors present a classification of trauma to the cranial base, based on observation in 80 cases. There are five types. Type I : involves only the anterior wall of the frontal sinus. Type II : involves the face (craniofacial disjunction of the Lefort II type or crush face) and extend upward to the cranial base and, in occurency, to the anterior wall of the frontal sinus, because of the facial retrusion. Type III : ivolves frontal part of the skull and extend down to the cranial base. Type IV : is a combination of types II and III. Type V : involves only ethmoidal or sphenoidal bones. Cerebrospinal fluid leak is unfrequent in types II, and transitionnal, if it occurs ; but it often occurs in types III, IV and V which include in every case a dural tear. Correct diagnosis facilitates treatment. Fractures of types I and II can be fully treated by maxillo-facial surgeons, whereas for types III, IV, and V, they need the help of a neuro-surgeon.