RESUMEN
Kidney transplantation significantly improves patient survival, and is the most cost effective renal replacement option compared with dialysis therapy. Living kidney donors provide a valuable societal gift, but face many formidable disincentive barriers that include not only short- and long-term health risks, but also concerns regarding financial expenditures and health insurance. Other than governmental coverage for their medical evaluation and surgical expenses, donors are often asked to personally bear a significant financial responsibility due to lost work wages and travel expenses. In order to alleviate this economic burden for donors, we advocate for the consideration of tax credits, lifelong health insurance coverage, and an outcomes registry as societal reciprocity to reward their altruistic act of kidney donation.
RESUMEN
The paper describes synthesis and antibacterial study of biologically active Mannich bases of carboxamide derivative employing Mannich reaction of 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide with various sulfonamides/secondary amines . They were analysed by elemental analysis and characterized by UV, IR and (1)H NMR spectroscopic studies. The Mannich bases were screened for antibacterial activity against various gram-negative bacteria at various concentrations and were analysed statistically. The result has shown that the compounds are quite active against pathogens under study and were non-toxic. All the synthesized compounds were found to be low lethal as ascertained by LD50 test.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/farmacología , Bases de Mannich/síntesis química , Naftacenos/síntesis química , Animales , Antibacterianos/toxicidad , Indicadores y Reactivos , Dosificación Letal Mediana , Espectroscopía de Resonancia Magnética , Bases de Mannich/toxicidad , Ratones , Naftacenos/farmacología , Pasteurella multocida/efectos de los fármacos , Salmonella enteritidis/efectos de los fármacos , Espectrofotometría Infrarroja , Espectrofotometría UltravioletaRESUMEN
Sulfa drugs are building blockers of several types of Mannich bases. Consequently, the antibacterial activities of sulfa drugs are reported in this paper, which will help in explaining and understanding antibacterial activities of Mannich bases. Reported QSAR is carried out using distance-based topological indices and discussed critically on the basis of statistical parameters.
Asunto(s)
Antibacterianos/farmacología , Bacterias/efectos de los fármacos , Bases de Mannich/química , Sulfanilamidas/farmacología , Antibacterianos/síntesis química , Relación Estructura-Actividad Cuantitativa , Estadística como Asunto , Sulfanilamidas/síntesis químicaRESUMEN
A series of novel Mannich bases derived from 5-chloro-2-methoxybenzamide and sulfonamides/amines have been synthesised and the antibacterial activities were evaluated against various Gram positive and Gram negative strains of bacteria. Some of the synthesized compounds showed superior in vitro activities as compared to their parent sulfonamides.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/química , Antibacterianos/farmacología , Técnicas In Vitro , Pruebas de Sensibilidad Microbiana , Análisis Espectral/métodosRESUMEN
Aromatic stabilities of acenes and helicenes, which are responsible for their biological, environmental and cancerous behavior have been modeled using a newly introduced Sadhana (Sd) and A indices. The results are compared with those obtained from PI (Padmakar-Ivan) index. The regression analysis has shown that excellent results are obtained by considering acenes and helicenes as separate classes of isomeric benzenoid hydrocarbons and that A index is better index than both PI and Sd indices.
Asunto(s)
Benceno/química , Compuestos Policíclicos/química , Modelos Químicos , Valor Predictivo de las Pruebas , Análisis de RegresiónRESUMEN
Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, 1H nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.
Asunto(s)
Antituberculosos/síntesis química , Antituberculosos/farmacología , Bases de Mannich/síntesis química , Aminas/síntesis química , Aminas/química , Aminas/toxicidad , Antituberculosos/química , Bacterias/efectos de los fármacos , Dosificación Letal Mediana , Bases de Mannich/química , Metilación , Estructura Molecular , Análisis EspectralRESUMEN
Attempt has been made to estimate the accuracy, predictive power, and domain of application of the PI (Padmakar-Ivan) index for modeling bioconcentration factor (BCF) of polyhalogenated biphenyls. Relative potential of PI index is investigated by comparing the results obtained using this index with those obtained from Wiener (W) and Szeged (Sz) indices. In addition, attempt has also been made to model hydrophobicity/lipophilicity (logP) of the polyhalogenated biphenyls using these indices. It was observed that these distance-based topological indices gave better results for modeling log BCF than logP.
Asunto(s)
Compuestos de Bifenilo/química , Compuestos de Bifenilo/farmacología , Modelos Químicos , Relación Estructura-Actividad CuantitativaRESUMEN
The paper describes synthesis and comparative study on antibacterial activities of sulphonamides and Mannich bases derived from them. The compounds were screened for their antibacterial activity against various gram-positive and gram-negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/farmacología , Bacterias/efectos de los fármacos , Bases de Mannich/química , Sulfonamidas/síntesis química , Sulfonamidas/farmacología , Animales , Dimetilsulfóxido , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Dosificación Letal Mediana , Espectroscopía de Resonancia Magnética , Masculino , Ratones , Pruebas de Sensibilidad Microbiana , Relación Estructura-Actividad Cuantitativa , Solventes , Espectrofotometría Infrarroja , Espectrofotometría Ultravioleta , Sulfonamidas/toxicidadRESUMEN
The aqueous solubility (S(w)) of liquids and solids, expressed as log S(w) as well as their partition coefficients in different solvent systems viz. P(oct) (partition coefficient in octanol-water), P(16) (partition coefficient in water-hexadecane), P(alk) (partition coefficient in water-alkane), and P(cyc) (partition coefficient in water-cyclohexane), and aqueous solubility (S(w)) have been estimated using the PI (Padmakar-Ivan) index and the results compared with those obtained using the widely used Wiener index (W). Regression analysis of the data using n-alkanes show that the PI index gives better results than the W index.