RESUMEN

Two new azaphilone pigments, talaralbols A and B (3 and 7), along with five known azaphilone metabolites (1, 2, and 4-6), were isolated from the culture of Talaromyces albobiverticillius associated with the isopod Armadillidium vulgare. Their structures were elucidated by a combination of 1 D and 2 D NMR data, ECD calculations, chemical transformations, and NMR data analogy with model compounds. Talaralbol A (3) showed a moderate inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with the inhibitory rate being 31.0% at the concentration of 10 µM.[Formula: see text].

Asunto(s)

Talaromyces , Animales , Antiinflamatorios/farmacología , Benzopiranos , Lipopolisacáridos/farmacología , Ratones , Estructura Molecular , Óxido Nítrico , Pigmentos Biológicos