RESUMEN
Anionic synthetic polypeptides are promising candidates as standalone bone-targeting drug carriers. Nevertheless, the structure-property relationship of the bone-targeting ability of polypeptides remains largely unexplored. Herein we report the optimization of the in vitro and in vivo bone-targeting ability of poly(glutamic acid)s (PGAs) by altering their chain lengths and backbone chirality. PGA 100-mers exhibited higher hydroxyapatite affinity in vitro, but their rapid macrophage clearance limited their targeting ability. Shorter PGA was therefore favored in terms of in vivo bone targeting. Meanwhile, the backbone chirality showed less significant impact on the in vitro and in vivo targeting behavior. This study highlights the modulation of structural parameters on the bone-targeting performance of anionic polypeptides, shedding light on the future design of polypeptide-based carriers.
Asunto(s)
Huesos , Ácido Poliglutámico , Ácido Poliglutámico/química , Ácido Poliglutámico/análogos & derivados , Animales , Huesos/efectos de los fármacos , Huesos/metabolismo , Ratones , Durapatita/química , Células RAW 264.7 , Portadores de Fármacos/química , Macrófagos/efectos de los fármacos , Macrófagos/metabolismoRESUMEN
Flexible strain sensors have shown great application value in wearable devices. In the past decades, researchers have spent numerous efforts on developing high-stretchability, excellent dynamic durability, and large linear working range flexible strain sensors and shaped a series of important research results. However, the viscoelasticity of the elastic polymer is always a big challenge to develop a flexible sensor. Here, to overcome this challenge, we developed a novel self-repairing carbon nanotubes/ethylene vinyl acetate (CNTs/EVA) fiber strain sensor prepared by embedding the CNTs on the surface of the swollen shape memory EVA fiber via the ultrasonic method. The CNTs/EVA fiber strain sensors responded with significant results, with high stretchability (190% strain), large linear working range (up to 88% strain), excellent dynamic durability (5000 cycles), and fast response speed (312 ms). In addition, the permanently damaged conductive network of the strain sensors, caused by the viscoelasticity of elastic polymer, can restore above the transforming temperature of the shape memory CNTs/EVA fiber. Moreover, the performance of the restored strain sensors was almost as same as that of the original strain sensors. Furthermore, human health monitoring tests show that the CNTs/EVA fiber has a broad application prospect for human health monitoring in wearable electronic devices.