RESUMEN
No disponible
Asunto(s)
Humanos , Masculino , Preescolar , Encefalopatías/etiología , Canal de Sodio Activado por Voltaje NAV1.8/genética , Epilepsia Tónico-Clónica/genética , Epilepsia Tónico-Clónica/complicaciones , Mutación/genéticaRESUMEN
Numerous patients who are prescribed antiepileptic drugs (AEDs) for epileptic seizures are already receiving other agents for the treatment of co-morbid conditions, which frequently occur alongside epilepsy. This raises additional clinical considerations and makes the use of AEDs with good safety profiles and fewer drug-drug interactions attractive. Second and third-generation anticonvulsant drugs are associated with fewer pharmacological interactions and improved tolerability compared with first-generation drugs. Furthermore, second and third-generation anticonvulsant drugs are associated with linear pharmacokinetic profiles and differing mechanisms of action, making them ideal for pluripathological and polymedicated patients. In this report, we highlight the efficacy of one such agent, lacosamide, in five patients with co-morbidities and unusual presentations of epilepsy, including a patient with paraneoplastic encephalitis caused by microcytic lung carcinoma, one with a brain tumour and one with Alzheimer's disease, as well as a case of catamenial epilepsy and one of refractory convulsive status epilepticus. In all patients, lacosamide was associated with a substantial reduction in seizure frequency and effective control of seizure episodes. Treatment was generally well tolerated in all patients, indicating that lacosamide is an effective treatment option for a variety of patients with epileptic seizures.
Asunto(s)
Acetamidas/uso terapéutico , Anticonvulsivantes/uso terapéutico , Epilepsia/tratamiento farmacológico , Acetamidas/efectos adversos , Acetamidas/farmacocinética , Adulto , Anciano de 80 o más Años , Anticonvulsivantes/efectos adversos , Anticonvulsivantes/farmacocinética , Interacciones Farmacológicas , Epilepsia/etiología , Epilepsia/fisiopatología , Femenino , Humanos , Lacosamida , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
Varón de 50 años, gastrectomizado y alcohólico, que consultó por unas lesiones cutáneas de distribución simétrica en áreas fotoexpuestas y alteraciones neurológicas leves. El tratamiento con suplementos vitamínicos y proteicos originó una rápida resolución de las lesiones cutáneas. La pelagra debe ser considerada ante un paciente desnutrido con fotodermatosis (AU)