RESUMEN

PURPOSE: Metastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency of the metastatic process. To compare protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) between primary tumours and metastatic tumours may be useful in illustrating these theories. METHODS: Metastasis-related tissue microarrays (including normal tissues, primary tumours, nodal metastases and liver metastases) were constructed. The protein expression of nm23, KISS1, KAI1 and p53 in lymph node and liver metastases from advanced gastric cancer specimens was mainly examined by immunohistochemical staining in relation to primary tumours. RESULTS: Immunohistochemical staining showed reduced protein expression of nm23, KISS1 and KAI1 in lymph node and liver metastases compared with primary tumours. Results for p53 were to the contrary. CONCLUSIONS: Our investigations revealed a tendency of reduced protein expression of metastasis suppressor genes nm23, KISS1 and KAI1 in gastric cancer with the progress of metastasis. This means that the progression theory is an important determinant of metastatic efficiency.

Asunto(s)

Biomarcadores de Tumor/análisis , Neoplasias Hepáticas/metabolismo , Neoplasias Hepáticas/secundario , Neoplasias Gástricas/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Expresión Génica , Perfilación de la Expresión Génica , Marcadores Genéticos , Humanos , Inmunohistoquímica , Proteína Kangai-1/análisis , Proteína Kangai-1/genética , Kisspeptinas , Metástasis Linfática , Masculino , Persona de Mediana Edad , Nucleósido Difosfato Quinasas NM23 , Nucleósido-Difosfato Quinasa/análisis , Nucleósido-Difosfato Quinasa/genética , Análisis de Secuencia por Matrices de Oligonucleótidos , Coloración y Etiquetado , Proteína p53 Supresora de Tumor/análisis , Proteína p53 Supresora de Tumor/genética , Proteínas Supresoras de Tumor/análisis , Proteínas Supresoras de Tumor/genética

RESUMEN

<p><b>OBJECTIVE</b>A survey on cancer patients at the community level in Shanghai was performed, in order to study the factors affecting the quality of life (QOL) on them.</p><p><b>METHODS</b>To evaluate the QOL of cancer patients, self-administered Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire and personal interview methods were used. Data analysis was performed by SPSS software (SPSS,Chicago, IL), including one-way ANOVA and linear regression methods.</p><p><b>RESULTS</b>There were 7580 valid questionnaires retrieved. Many factors were certificated to have significant relationship with QOL of cancer patients,such as family incomes, education, occupation, awareness of disease, physical exercise, cost of health care and pain (P < 0.01). Some factors however, only affecting certain aspects of the QOL, of which age, marriage state, type of tumor and stage were also noticed. KPS had strong Linear correlation with every aspect of FACT-G (P < 0.000).</p><p><b>CONCLUSION</b>Patients having a poor KPS, metastasis, low educational level, divorced or lost of spouse, pain, poor income, little exercise and old age would tend to have a poor QOL outcome.</p>

Asunto(s)

Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , China , Demografía , Encuestas Epidemiológicas , Estadificación de Neoplasias , Neoplasias , Patología , Calidad de Vida , Características de la Residencia

RESUMEN

<p><b>OBJECTIVE</b>To detect the short-term clinical and side effects of cryosurgical ablation for prostate cancer.</p><p><b>METHODS</b>The ENDOCAm cryosurgical system with 2 mm Cryo-probes was used to treat the prostate cancer guided by rectal ultrasonic. 1. Completeness of freeze; 2. Complications; 3. The changes of PSA and PSMA before and after operation were observed respectively.</p><p><b>RESULTS</b>1. The completeness of freeze rate and non-completeness of freeze rate were 34.8% (8/23) and 65.2% (15/23) showed by MRI 3 weeks later after operation; the biopsy results showed that tumor positive rates in completeness of freeze group and non-completeness of freeze group were 0 and 20% (3/15) respectively after 6 months. 2. The incontinence rate was 13%, and all recovered during 1 month; and the erectile dysfunction rate post-operation was 56.2% (9/16). 3. The levels of PSA before and after cryosurgical ablation were (32.98 +/- 35. 50) microg/L, (11.65 +/- 26. 51) microg/L respectively (P < 0.05). PSMA increased significantly after the cryosurgical ablation.</p><p><b>CONCLUSION</b>The short-term curative effects of cryosurgical ablation, which guided by rectal ultrasound for prostate cancer is satisfied with low complication rate and minor vulnus.</p>

Asunto(s)

Adulto , Anciano , Anciano de 80 o más Años , Humanos , Masculino , Persona de Mediana Edad , Criocirugía , Métodos , Estudios de Seguimiento , Antígeno Prostático Específico , Sangre , Neoplasias de la Próstata , Patología , Cirugía General , Recto , Diagnóstico por Imagen , Ultrasonografía