RESUMEN
We report the case of a 30-year-old woman with a rare presentation of early adulthood Huntington's disease (HD) with hypersexuality. It is not known if sexual dysfunction in HD patients is due to a specific brain lesion or adverse psychosocial factors associated with HD. Although there are no evidence-based treatment guidelines for hypersexuality in HD, our patient exhibited significant improvement with olanzapine and haloperidol.
Asunto(s)
Enfermedad de Huntington/diagnóstico , Enfermedad de Huntington/psicología , Disfunciones Sexuales Fisiológicas/psicología , Disfunciones Sexuales Psicológicas/psicología , Adulto , Antipsicóticos/uso terapéutico , Benzodiazepinas/uso terapéutico , Femenino , Haloperidol/uso terapéutico , Humanos , Enfermedad de Huntington/complicaciones , Olanzapina , Conducta Sexual , Disfunciones Sexuales Fisiológicas/complicaciones , Disfunciones Sexuales Fisiológicas/diagnóstico , Disfunciones Sexuales Psicológicas/complicaciones , Disfunciones Sexuales Psicológicas/diagnóstico , Resultado del TratamientoRESUMEN
Physicochemical properties and systemic effects of the enterotoxin of Klebsiella pneumoniae has been studied. The enterotoxin had a molecular weight between 10 000 to 50 000. It was protein in nature, and heat and acid stable, inducing a dilatatory response in the gut. It haemolyzed the erythrocytes of various animals including man. It had a capillary permeability activity. In addition, when administered parenterally it increased the level of blood glucose, serum cholesterol, serum alkaline phosphatase and serum acid phosphatase.
Asunto(s)
Enterotoxinas/farmacología , Klebsiella pneumoniae/análisis , Fosfatasa Ácida/sangre , Fosfatasa Alcalina/sangre , Animales , Proteínas Bacterianas/análisis , Glucemia/metabolismo , Permeabilidad Capilar/efectos de los fármacos , Colesterol/sangre , Enterotoxinas/análisis , Hemólisis/efectos de los fármacos , Calor , Concentración de Iones de Hidrógeno , Peso Molecular , ConejosRESUMEN
Klebsiella pneumoniae strain B-5-1 was used to study the effect of its enterotoxin on the intestinal transport and histopathological changes in the rabbit ileal loop. Enterotoxin increased the net flux of water and of electrolytes. Increased amounts of phospholipids and proteins were also detected together with structural and functional abnormalities in the ileum. All these suggest that K. pneumoniae enterotoxin not only induce a net flux of fluid and imbalance of electrolytes but also damages the intestinal structure.