RESUMEN
The case report of a 16-month-old girl with lamellar ichthyosis and unilateral megalocornea is presented. This is a previously unrecorded association and the first report of a unilateral megalocornea in a female.
Asunto(s)
Córnea/anomalías , Ictiosis/genética , Biopsia , Ectropión/patología , Femenino , Humanos , Ictiosis/clasificación , Ictiosis/complicaciones , Ictiosis/patología , Lactante , Queratosis/patología , Piel/patología , Lengua/patologíaAsunto(s)
Enfermedades Autoinmunes/complicaciones , Candidiasis Mucocutánea Crónica/complicaciones , Candidiasis/complicaciones , Enfermedades del Sistema Endocrino/complicaciones , Oftalmopatías/complicaciones , Enfermedad de Addison/complicaciones , Adolescente , Femenino , Humanos , Masculino , SíndromeRESUMEN
We report on two sisters born to normal but consanguineous parents, with the unusual combination of spinocerebellar degeneration and corneal dystrophy. Their manifestations include mental subnormality, bilateral corneal opacification starting in the second year of life and leading to severe visual impairment, and slowly progressive cerebellar abnormalities with variable dorsal column and upper motor neuron involvement. A third sister had only minor spinocerebellar signs but no eye findings, and three other sibs were completely normal. Both affected sisters underwent penetrating keratoplasty and their vision improved. Histologic examination showed findings of corneal dystrophy including corneal edema, thickening of Descemet membrane, and degenerative pannus. High-resolution light and electron microscopy of muscle and sural nerve performed on both patients was abnormal. It is suggested that, in this family, the corneal dystrophy and spinocerebellar degeneration are pleiotropic manifestations of an autosomal-recessive disorder.
Asunto(s)
Enfermedades Cerebelosas/genética , Consanguinidad , Distrofias Hereditarias de la Córnea/genética , Genes Recesivos , Enfermedades de la Médula Espinal/genética , Adolescente , Adulto , Biopsia , Enfermedades Cerebelosas/patología , Córnea/patología , Distrofias Hereditarias de la Córnea/patología , Femenino , Humanos , Masculino , Microscopía Electrónica , Músculos/patología , Examen Neurológico , Linaje , Enfermedades de la Médula Espinal/patología , Nervio Sural/patología , SíndromeRESUMEN
One hundred twenty patients who met criteria for presumptive bacterial infections of the conjunctiva were closely recorded for two weeks in a double-blind study that compared the effectiveness of gentamicin with a combination of neomycin and polymyxin B sulfates. The neomycin and polymyxin B combination demonstrated statistical superiority as measured by patient improvement and failure to respond to therapy. However, difficulties including chance distribution of bacteria and variability of organism resistance may have detracted from statistical results.
Asunto(s)
Antibacterianos/uso terapéutico , Infecciones Bacterianas/tratamiento farmacológico , Conjuntivitis/tratamiento farmacológico , Ensayos Clínicos como Asunto , Combinación de Medicamentos , Estudios de Seguimiento , Gentamicinas/farmacología , Gentamicinas/uso terapéutico , Humanos , Pruebas de Sensibilidad Microbiana , Neomicina/farmacología , Neomicina/uso terapéutico , Polimixinas/farmacología , Polimixinas/uso terapéutico , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus/efectos de los fármacos , Infecciones Estreptocócicas/tratamiento farmacológico , Streptococcus/efectos de los fármacosRESUMEN
The biologically available concentration of gentamicine sulfate in eight ocular tissues of 140 rabbits and 96 humans was measured by a modified disc diffusion technique. If enough topically administered gentamicine was applied, this bioassay detected it in all ocular tissues tested except the lens nucleus. The decay of antibiotic activity was faster in some tissues, eg, aqueous, than in others. A higher level of antibiotic was found in corneas altered by sutures than in virgin tissue. The degree of inflammation, the frequency of application, and the interval between the drops are directly proportional to the antibiotic level in the tissues. The antibiotic free vehicle of commercial 0.3 per cent gentamicin drops possesses an antibacterial potential.