RESUMEN

The fluorine-18 labeled nortropane derivative 2ß-carbomethoxy-3ß-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane (FECNT) is a dopamine transporter (DAT) ligand. Currently, it is considered as reference for positron emission tomography imaging. Herein, the synthesis of novel precursors (N-tosyloxy-, chloro-, and bromo- analogues) for one-step radiosynthesis of [(18)F]FECNT is reported. Using the N-mesyloxy- precursor in a one-step radiosynthesis, the crude [(18)F]FECNT was obtained with the radiolabeling yield of 45 ± 10%, confirming the practical efficiency of this approach in the design of novel precursors for labeling.

Asunto(s)

Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/metabolismo , Nortropanos/síntesis química , Nortropanos/metabolismo , Tomografía de Emisión de Positrones , Técnicas de Química Sintética , Ligandos , Nortropanos/química , Radioquímica