RESUMEN

OBJECTIVE: We have determined Coenzyme Q(10) (CoQ(10)) levels in salivary cells (SCs) and mononuclear blood cells (BMCs) from Fibromyalgia (FM), and we study the influence of oral CoQ(10) supplementation on cells levels and clinical symptoms. METHODS: CoQ(10) was determined by high-performance liquid chromatography (HPLC). Ten patients were supplemented daily with 300 mg of CoQ(10) during 3 months. RESULTS: CoQ(10) were reduced in both cell models. Oral supplementation showed an improvement in clinical symptoms and restored levels. CONCLUSIONS: Patients with FM showed an important dysfunction in CoQ(10) levels and might benefit from oral supplementation.

Asunto(s)

Fibromialgia/sangre , Leucocitos Mononucleares/metabolismo , Conductos Salivales/patología , Ubiquinona/análogos & derivados , Vitaminas/uso terapéutico , Adulto , Estudios de Casos y Controles , Suplementos Dietéticos , Fibromialgia/tratamiento farmacológico , Fibromialgia/patología , Humanos , Persona de Mediana Edad , Conductos Salivales/metabolismo , Resultado del Tratamiento , Ubiquinona/deficiencia , Ubiquinona/farmacocinética , Ubiquinona/uso terapéutico , Vitaminas/farmacocinética