RESUMEN

The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding.

Asunto(s)

Apoptosis/efectos de los fármacos , Rifabutina/análogos & derivados , Proteína bcl-X/química , Línea Celular Tumoral , Humanos , Rifabutina/química , Rifabutina/farmacología