RESUMEN
Dengue is a common viral infection worldwide, though its neurological manifestations are infrequent (2%-11% in recent years) and can be varied as the Dengue virus per se is a non-neurotropic virus. Neurological manifestations of Dengue usually result from multisystem dysfunction which may be secondary to vascular leak or it can be due to direct virus invasion (dengue encephalitis) or an immunological phenomenon which is triggered by dengue infection (demyelinating disorders). Here we present two cases of dengue fever associated demyelinating disorders in two pediatric patients aptly depicting the two spectra of the disease. One of them is a case of fatal acute hemorrhagic leukoencephalopathy (AHLE) in a 3-year-old girl, that developed severe neurological sequelae while the other one is a case of an Acute disseminated Encephalomyelitis (ADEM) in a 3-year-old boy who had recovered with timely immunomodulatory therapy and appropriate management.
Asunto(s)
Dengue , Encefalitis , Encefalomielitis Aguda Diseminada , Niño , Preescolar , Dengue/complicaciones , Dengue/diagnóstico , Encefalitis/complicaciones , Encefalomielitis Aguda Diseminada/complicaciones , Encefalomielitis Aguda Diseminada/etiología , Femenino , Humanos , MasculinoRESUMEN
Dengue illness is characterised by plasma leakage with or without bleeding, which may lead to dengue shock syndrome. Proteinuria and hypoalbuminaemia are common in dengue infection, and few cases of heavy proteinuria have been reported. Dengue infection features may mimic nephrotic syndrome in clinical practice. As dengue infection is endemic in India, it can be associated with other illnesses such as nephrotic syndrome. We report a child with nephrotic syndrome complicated with severe dengue infection.