RESUMEN
Towards the improvement of predicting and analyzing the infection transmission, a novel CNN (Convolution Neural Network) based Covid Infection Transmission Analysis (CNN-CITA) is presented in this article. The method works based on both GIS data set and the Covid data set. The method reads all the data from the data sets. From the remote sensing data, the method extracts different climate conditions like temperature, humidity, and rainfall. Similarly from Global Information System data set, the locations of the peoples are fetched and merged. The merged data has been split into number of time frame, at each condition, the data sets are merged. Such merged data has been trained with deep learning networks which support the search of person location and mobility. Based on the result and the data set maintained by the governments, the infection transmission rate has been measured on region basis. In each region of movement performed by any person, the method computes the infection Transmission Rate (ITR) in two time window as before and after. According to the infection rate and ITR value of different region, a subset of sources are selected as vulnerable sources. The method produces higher performance in predicting the vulnerable sources and supports the reduction of infection rate.
RESUMEN
The spiro[chromane-2,4'-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4'-piperidine]-4(3H)-one-derived compoundsin the recent years and focuses on features of their biological relevance's. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4'-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.
Asunto(s)
Química Farmacéutica , Cromanos/química , Piperidinas/química , Compuestos de Espiro/química , Acetil-CoA Carboxilasa/antagonistas & inhibidores , Acetil-CoA Carboxilasa/metabolismo , Antioxidantes/química , Anhidrasas Carbónicas/química , Anhidrasas Carbónicas/metabolismo , Diseño de Fármacos , Humanos , Simulación del Acoplamiento Molecular , Isoformas de Proteínas/antagonistas & inhibidores , Isoformas de Proteínas/metabolismo , Compuestos de Espiro/metabolismo , Relación Estructura-ActividadRESUMEN
A novel Mg3N2-assisted one-pot annulation strategy has been developed via cyclo-condensation reaction of 2-pyridyl ketones with alkyl glyoxylates or aldehydes, allowing the formation of imidazo[1,5-a]pyridines exclusively with an exellent yield.
RESUMEN
A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of (1)H NMR, (13)C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.