RESUMEN
The influence of polyclonal anti-ovarian and monoclonal antibodies, reacting with cell surface membrane, on the electrical activity of mouse oocytes was studied by the intracellular microelectrode recording. The data obtained suggest that specific antibodies alter permeability and excitability of sexual cells.
Asunto(s)
Autoanticuerpos/inmunología , Potenciales de Acción/fisiología , Animales , Especificidad de Anticuerpos/fisiología , Membrana Celular/fisiología , Permeabilidad de la Membrana Celular/fisiología , Femenino , Técnicas In Vitro , Ratones , Ratones Endogámicos CBA , Oocitos/inmunología , Oocitos/ultraestructuraRESUMEN
Analyzes the findings of histologic studies of biopsies of a pathologically changed and visually intact bladder mucosa from 334 patients with chronic cystitis with nonproliferative, proliferative, and metaplastic changes (n = 164), papillomas (n = 62), and carcinomas (n = 108). Demonstrates the relationships between these conditions and their evolution over a follow-up of 36-72 months. Outlines the most typical patterns of their development and progress eventuating in noninvasive or various forms of invasive carcinoma.
Asunto(s)
Cistitis/patología , Papiloma/patología , Lesiones Precancerosas/patología , Neoplasias de la Vejiga Urinaria/patología , Biopsia , Transformación Celular Neoplásica/patología , Enfermedad Crónica , Cistitis/complicaciones , Epitelio/patología , Humanos , Metaplasia/patología , Lesiones Precancerosas/etiología , Estudios Retrospectivos , Factores de Riesgo , Vejiga Urinaria/patología , Neoplasias de la Vejiga Urinaria/etiologíaRESUMEN
The electron-microscopic analysis of 65 different transitional-cell tumours of the urinary bladder revealed quantitative correlations between the tumour cells belonging to different groups, types and forms of transitional-cell papilloma, transitional-cell carcinoma and undifferentiated carcinoma of the bladder. These correlations are of importance for histogenetic and differential diagnosis of these tumours. The correlation between the changes in cell composition of transitional-cell papilloma or transitional-cell carcinoma and the subsequent clinical course of the disease (prognosis) is determined.
Asunto(s)
Carcinoma de Células Transicionales/diagnóstico , Neoplasias de la Vejiga Urinaria/diagnóstico , Carcinoma de Células Transicionales/ultraestructura , Epitelio/ultraestructura , Estudios de Seguimiento , Humanos , Microscopía Electrónica , Recurrencia Local de Neoplasia/diagnóstico , Recurrencia Local de Neoplasia/ultraestructura , Papiloma/diagnóstico , Papiloma/ultraestructura , Pronóstico , Neoplasias de la Vejiga Urinaria/ultraestructuraRESUMEN
The urinary bladder leukoplakia from 42 patients was studied clinico-morphologically, histochemically and electron microscopically. This precancerous condition is observed in 58,3 cases of chronic cystitis, more frequently in females. Three successive stages of the leukoplakia development under the conditions of the inflammatory process can be distinguished: squamous-cell modulation, squamous-cell metaplasia, squamous-cell metaplasia with keratinization. The formation of fissure-like intercellular bridges and the appearance of the long dense bundles of tonofibrils in the cytoplasm are the early ultrastructural signs of squamous-cell metaplasia of the transitional epithelium which are of the differential-diagnostic importance.