RESUMEN
The mechanisms of endocrine and immune system disorders in normal and disturbed pregnancy as well as in chorionocarcinoma, hydatid mole, metastatic and non-metastatic chorionocarcinoma have been investigated. Relevant disorders were chiefly caused by the endocrine function of the thymus and gonadotropins from the trophoblast, which made a powerful impact on the periphery of hormonal and immunological homeostasis. Unlike normal pregnancy, gestational trophoblastic disease involved changes in the nature, direction and degree of correlations between endocrine formations, which in turn determined the pathogenetic pattern of the disease.
Asunto(s)
Coriocarcinoma/fisiopatología , Glándulas Endocrinas/fisiopatología , Timo/fisiopatología , Neoplasias Uterinas/fisiopatología , Femenino , HumanosRESUMEN
The levels of embryonic antigens (cancer embryonic antigen, alpha-fetoprotein, beta-chorionic gonadotropin were measured in the serum, spinal fluid, the cystic fluid of tumor 83 of neuro-oncological patients. It was found that the blood concentrations of cancer embryonic antigen and alpha-fetoprotein were not generally related to the degree of malignancy and the blood level of beta-chorionic gonadotropin decreased with the higher degree of tumor anaplasia. The high content of beta-chorionic gonadotropin in the spinal fluid suggests its origin from a brain tumor. The fatal postoperative outcome was noted in patients having high preoperative serum levels of alpha-fetoprotein and cancer embryonic antigen with simultaneous much higher concentrations of alpha-fetoprotein in the serum than those in the spinal fluid.
Asunto(s)
Astrocitoma/diagnóstico , Biomarcadores de Tumor/análisis , Neoplasias Encefálicas/diagnóstico , Antígeno Carcinoembrionario/análisis , Gonadotropina Coriónica/análisis , Glioblastoma/diagnóstico , alfa-Fetoproteínas/análisis , Anaplasia/diagnóstico , Anaplasia/cirugía , Astrocitoma/cirugía , Encéfalo/patología , Neoplasias Encefálicas/cirugía , Glioblastoma/cirugía , Humanos , Técnicas para Inmunoenzimas/estadística & datos numéricos , Periodo Intraoperatorio , Periodo Posoperatorio , Factores de TiempoRESUMEN
Combined versus separate exposure of male organism to cesium-137 and chemical agents results in a more pronounced hyperferritinemia in the former case. In female chemists the ferritin level is dependent to a considerable extent on the menstrual cycle showing a tendency for the iron-containing protein level to decrease because of the action of a number of chemical agents. The rise of the level of cancer embryonic antigen is more readily seen in persons with high levels of cesium-137. Concentrations of carbohydrate antigen (CA-125) and mucin-like antigen are appreciably higher in female chemists incorporating cesium-137, and in those within the 30-km radius of the ChNPP. The level of thyroglobulin was raised in the chemists having a background incorporation of cesium, the liquidators of the aftermaths, and particularly in those happened to be in the 30-km zone. Each of the unfavourable factors taken separately (chemical agent or cesium-137) had lesser effect on the degree of elevation of TG content and hormone-forming function of the thyroid gland. An additional information has been obtained concerning the risk groups, which, however, serves as an indirect measure of carcinogenic effect various environmental factors exert on the organism.
Asunto(s)
Biomarcadores de Tumor/sangre , Contaminación Ambiental/efectos adversos , Glándula Tiroides/efectos de los fármacos , Adulto , Biomarcadores de Tumor/efectos de la radiación , Industria Química , Femenino , Humanos , Masculino , Centrales Eléctricas , Liberación de Radiactividad Peligrosa , Tiroglobulina/sangre , Tiroglobulina/efectos de los fármacos , Tiroglobulina/efectos de la radiación , Glándula Tiroides/fisiología , Glándula Tiroides/efectos de la radiación , Hormonas Tiroideas/sangre , Hormonas Tiroideas/efectos de la radiación , Ucrania , Población UrbanaRESUMEN
Groups at risk for malignant neoplasia were identified among workmen occupationally exposed to different chemical substances, using immunoradiometric and enzyme immunoassays of tumor-associated antigens. Exposure to the above occupational hazard was found to affect the workmen and cause certain chronic illness accompanied by some increase in concentration of a number of tumoral markers. Increase in tumour antigens suggests indirectly that the chemical substances may have carcinogenic activity. We have every reason to recommend these tests as an additional method for identification of groups at high risk for subsequent development of tumours in the digestive system and reproductive organs of persons occupationally exposed to chemical substances.
Asunto(s)
Biomarcadores de Tumor/sangre , Carcinógenos/toxicidad , Sustancias Peligrosas/efectos adversos , Exposición Profesional/efectos adversos , Antígenos de Carbohidratos Asociados a Tumores/sangre , Antígenos de Carbohidratos Asociados a Tumores/efectos de los fármacos , Antígeno Ca-125/sangre , Antígeno Ca-125/efectos de los fármacos , Antígeno CA-19-9/sangre , Antígeno CA-19-9/efectos de los fármacos , Antígeno Carcinoembrionario/sangre , Antígeno Carcinoembrionario/efectos de los fármacos , Femenino , Ferritinas/sangre , Ferritinas/efectos de los fármacos , Humanos , Masculino , Exposición Profesional/análisis , Exposición Profesional/estadística & datos numéricos , Factores de Riesgo , alfa-Fetoproteínas/análisis , alfa-Fetoproteínas/efectos de los fármacosRESUMEN
43 women with physiologically proceeding pregnancy have been examined during 1st, 2nd and 3d terms. The control group consists of 28 practically healthy non-pregnant women. It is stated that during pregnancy essential changes in the function of endocrine glands of mother take place. the appearance of placenta, a new gland of internal secretion, producing choriogonadotropin (CG) as well as the great amount of other hormones of the steroid and protein nature causes essential changes in the regulatory mechanisms underlying the physiological activity of internal secretion glands in mother. The development and early functioning of the internal secretion glands of a fetus promote the hormonal shifts. With the pregnancy development the number of estrogen increases hundred times, relative to their production in non-pregnant women secretion of progesterone and prolactin increase ten times. The functional activity of anterior lobe of the hypophysis, manifesting itself in hypersecretion of adrenocorticotropic hormone inhibition of follicule-stimulating hormone production changes as well. Changes in the functional state of the adrenal gland cortex: cortisole secretion is high are found.
Asunto(s)
Adaptación Fisiológica , Homeostasis/fisiología , Neuroinmunomodulación/fisiología , Sistemas Neurosecretores/fisiología , Embarazo/fisiología , Adulto , Gonadotropina Coriónica/metabolismo , Cortisona/metabolismo , Femenino , Humanos , Embarazo/sangre , Hormonas del Timo/sangreRESUMEN
Hyperproduction of chorionic gonadotropin was shown to be the first link in the chain of hormonal disturbances involved in trophoblastic disease, which induced changes of pituitary gonadotropic function. Ovarian function is affected by disturbances in trophoblastic and pituitary gonadotropic functions and depends on the extension and severity of the disease. This makes a case for corrective hormonal therapy in chorionepithelioma patients resistant to cytostatic or substitution therapy with sex hormones and in whom ovaries have been removed during combined treatment.
Asunto(s)
Glándulas Suprarrenales/fisiopatología , Ovario/fisiopatología , Hipófisis/fisiopatología , Neoplasias Trofoblásticas/fisiopatología , Neoplasias Uterinas/fisiopatología , Adolescente , Adulto , Coriocarcinoma/fisiopatología , Coriocarcinoma/terapia , Femenino , Humanos , Mola Hidatiforme/fisiopatología , Mola Hidatiforme/terapia , Persona de Mediana Edad , Metástasis de la Neoplasia , Embarazo , Factores de Tiempo , Neoplasias Trofoblásticas/terapia , Neoplasias Uterinas/terapiaRESUMEN
The diagnostic value of determinations of the levels of chorionic gonadotropin (HCG) and trophoblastic beta 1-glycoprotein (TBG) was studied in 160 cases of trophoblastic disease. Trophoblastic disease was diagnosed in 86% of cases, when HCG level was determined immunologically and in 100 % -- by radioimmunological means and in 86 and 33% when TBG level was established by immunoradioautographical and immunodiffusion methods, respectively. The results of HCG and TBG assays by immunological and immunoradioautographical methods matched in 96% of cases. The said methods are highly specific and may find a wide application in diagnosing trophoblastic disease. The radioimmunological method of HCG assay is the most sensitive. However, in view of possible HCG synthesis in cases of other tumor, its application should be preferred in assessing the efficacy of therapy rather than for primary diagnosis of trophoblastic disease.