Asunto(s)
Péptidos beta-Amiloides/antagonistas & inhibidores , Fulerenos/química , Fragmentos de Péptidos/antagonistas & inhibidores , Péptidos beta-Amiloides/metabolismo , Péptidos beta-Amiloides/toxicidad , Animales , Benzotiazoles , Células PC12 , Fragmentos de Péptidos/metabolismo , Fragmentos de Péptidos/toxicidad , Fotólisis , Ratas , Espectrometría de Fluorescencia , Tiazoles/metabolismoRESUMEN
We report a case of progressive prostatic carcinoma in a patient with acquired hypogonadism. An 86- year-old man was admitted to our hospital complaining of weakened urinary flow. He had had hypophysectomy because of a pituitary tumor at 75 years old. Needle biopsy of the prostate showed poorly differentiated adenocarcinoma in the whole region and bone scan revealed bone metastasis of right scapula. The patient was treated with anti-androgen monotherapy because of secondary hypogonadism, but the prostate specific antigen score, continued to increase. Despite secondary anti-androgen and steroid therapy, he died 13 months after admission.
Asunto(s)
Adenocarcinoma/complicaciones , Hipogonadismo/complicaciones , Neoplasias de la Próstata/complicaciones , Adenocarcinoma/diagnóstico , Adenocarcinoma/tratamiento farmacológico , Anciano de 80 o más Años , Antagonistas de Andrógenos/uso terapéutico , Neoplasias Óseas/secundario , Progresión de la Enfermedad , Resultado Fatal , Humanos , Masculino , Neoplasias de la Próstata/diagnóstico , Neoplasias de la Próstata/tratamiento farmacológicoRESUMEN
We report two cases of spontaneous urinary rupture caused by primary ureteral or renal pelvic cancer. Case 1: A 76-year-old man presented with macrohematuria and left back pain. Magnetic resonance imaging showed left middle ureteral tumor and rupture of upper ureter. Left nephroureterectomy was performed. Histological findings revealed urothelial carcinoma, G2, pT1, lt-u0, ew0, ly0, v1. At five months postoperatively, he died of lymph node metastases after two courses of adjuvant chemotherapy. Case 2: A 59-year-old man presented with macrohematuria and left back pain. Computer tomography showed left renal pelvic tumor with extravasation of urine. Left nephroureterectomy was performed. Examination of surgical specimen revealed a renal pelvic tumor and rupture hole at the renal pelvis. Histological finding revealed urothelial carcinoma, G3, pT3, lt-u0, ly0, v1. One course of adjuvant chemotherapy was performed. At six months postoperatively, he was free from recurrence.