RESUMEN
A 23-month-old, male, Labrador retriever dog with a history of slowly progressive right-sided atrophy of the masticatory muscles was submitted for necropsy. A highly invasive neoplasm which destroyed adjacent soft tissues including the right trigeminal nerve was found in the right side of the cranial cavity. Metastases to the liver were also present. Microscopical features of the neoplasm were compatible with those of rhabdomyosarcoma, embryonal type. This diagnosis was confirmed by immunohistochemical demonstration of desmin and muscle actin within tumour cells. In human patients, rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence. Parameningeal rhabdomyosarcomas are well-known topographic variants that are often non-amenable to complete surgical resection and therefore carry a more guarded prognosis. Juvenile parameningeal rhabdomyosarcoma resulting in denervation atrophy of the muscles of mastication has not been reported previously in dogs. Rhabdomyosarcoma should be included in the differential diagnosis of neoplastic conditions in the head and neck region of juvenile dogs presented with cranial nerve palsies or other neurological deficits suggestive of meningeal or central nervous system invasion.
Asunto(s)
Enfermedades de los Perros/patología , Neoplasias de Cabeza y Cuello/veterinaria , Neoplasias Meníngeas/veterinaria , Rabdomiosarcoma Embrionario/veterinaria , Actinas/análisis , Animales , Desmina/análisis , Perros , Resultado Fatal , Neoplasias de Cabeza y Cuello/patología , Inmunohistoquímica/veterinaria , Neoplasias Hepáticas/secundario , Neoplasias Hepáticas/veterinaria , Masculino , Neoplasias Meníngeas/química , Neoplasias Meníngeas/patología , Rabdomiosarcoma Embrionario/química , Rabdomiosarcoma Embrionario/secundarioRESUMEN
Adenocarcinoma of sweat glands of the footpads was diagnosed in 2 cats. Clinical signs included lameness and swelling of multiple digits. Pulmonary metastasis was detected in one case. Diagnosis was based on histopathological and immunohistochemical findings. Eccrine adenocarcinoma should be included in the differential diagnosis of footpads lesions in aged cats.