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[Admixture of related substances in rifampicin preparations and methods for their determination]. / Primesi rodstvennykh veshchestv v preparatakh rifampitsina i metody ikh opredeleniia.

Zak, A F; Snezhnova, L P; Shatrova, V M; Polisar, R D; Il'inskaia, N A.

Antibiotiki ; 27(8): 569-73, 1982 Aug.

Artículo en Ruso | MEDLINE | ID: mdl-7125614

RESUMEN

Optimal conditions for separation of rifampicin in a thin layer of a sorbent were developed. This allowed one to study the quantitative content of the admixtures of the related substances in the eluates of the respective spots on chromatograms. The possible use of both the spectrophotometric method and the biological agar diffusion method for testing the eluates was shown. The method of phase solubility also provided objective characterization of the purity levels of market rifampicin. A significant increase in the level of the admixtures of the related substances in rifampicin in 150 mg capsules was found on their storage.

Asunto(s)

Contaminación de Medicamentos , Rifampin/análisis , Cápsulas , Cromatografía en Capa Delgada/métodos , Estabilidad de Medicamentos , Almacenaje de Medicamentos , Quinonas/análisis , Espectrofotometría/métodos

[Embryotoxic effect of several pesticides]. / K voprosu ob émbriotoksicheskom deistvii nekotorykh pestitsidov.

Dinerman, A A; Lavrent'eva, N A; Il'inskaia, N A.

Gig Sanit ; 35(7): 39-42, 1970 Jul.

Artículo en Ruso | MEDLINE | ID: mdl-5507995

Asunto(s)

Embrión de Mamíferos/efectos de los fármacos , Plaguicidas/toxicidad , Animales , Embrión de Pollo , Desarrollo Embrionario y Fetal , Métodos , Ratas

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