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1.
J Clin Exp Hematop ; 64(1): 37-44, 2024 Mar 28.
Artículo en Inglés | MEDLINE | ID: mdl-38281744

RESUMEN

Peritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomatosa of unknown origin, exploratory laparoscopy was performed that revealed multiple white nodules and masses on the surfaces of the peritoneum, mesentery, and intestinal serosa. The histopathological and cytogenetic findings of the peritoneum revealed high-grade B-cell lymphoma, not otherwise specified, and a gain of MYC by fluorescence in-situ hybridization. The patient was treated with two cycles of R-CHOP therapy, followed by six cycles of dose-adjusted EPOCH-R therapy, and a complete metabolic response was confirmed by PET-CT. Since there are no specific radiological findings to confirm the diagnosis of PL, a histopathological diagnosis is usually required. Most PL exhibit an aggressive lymphoma phenotype and can be cured by appropriate chemotherapy. Therefore, early diagnosis and treatment are desirable.


Asunto(s)
Linfoma de Células B , Linfoma de Células B Grandes Difuso , Linfoma , Neoplasias Peritoneales , Masculino , Humanos , Anciano de 80 o más Años , Peritoneo/patología , Tomografía Computarizada por Tomografía de Emisión de Positrones , Neoplasias Peritoneales/diagnóstico , Neoplasias Peritoneales/tratamiento farmacológico , Neoplasias Peritoneales/patología , Linfoma de Células B/diagnóstico , Linfoma de Células B/tratamiento farmacológico , Linfoma de Células B/patología , Linfoma/patología , Prednisona/uso terapéutico , Rituximab/uso terapéutico , Vincristina/uso terapéutico , Ciclofosfamida/uso terapéutico , Doxorrubicina/uso terapéutico , Etopósido/uso terapéutico , Linfoma de Células B Grandes Difuso/patología
2.
Intern Med ; 62(11): 1675-1681, 2023 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-36070944

RESUMEN

TAFRO syndrome, a rare systemic inflammatory disorder, commonly develops in an acute or subacute manner, with an aggressive clinical behavior. A substantial number of cases of TAFRO syndrome presenting with abdominal pain, and adrenal abnormalities on imaging have also been reported. A 54-year-old man developed severe acute abdominal pain. Bilateral adrenal swelling was detected on computed tomography. Although the abdominal pain resolved spontaneously, a fever and anasarca were observed. The patient was eventually diagnosed with TAFRO syndrome, and corticosteroid administration resulted in remission. TAFRO syndrome should be included in the differential diagnosis of acute abdomen and adrenal abnormalities.


Asunto(s)
Abdomen Agudo , Enfermedad de Castleman , Masculino , Humanos , Persona de Mediana Edad , Abdomen Agudo/etiología , Corticoesteroides/uso terapéutico , Enfermedad de Castleman/diagnóstico , Edema/etiología , Edema/diagnóstico , Dolor Abdominal/etiología
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