RESUMEN
An experimental and prophylactic study was performed in an organized population of 1563 men aged 20-59 years engaged in scientific work. Intervention was realized in a group at high risk, mainly at the expense of changes in nutrition. After 3 years the main group demonstrated the lowering of the total caloricity of nutrition, consumption of food cholesterol and refined sugar together with the rise of animal protein, poly- and monounsaturated fatty acids (PUFA and MUFA) and complex carbohydrates consumption, leading to reduction of risk factors for coronary disease. After 3 years the control group manifested a decrease of sugar and a rise of complex carbohydrates consumption, which was not associated with changes in risk factors. It has been established using a multiple step-by-step regression analysis that the greatest effect on the drop of blood plasma cholesterol was produced by body weight reduction and diminution of the content of SFA in the diet whereas the decrease of arterial pressure by body weight reduction and the rise of the PUFA portion in the diet.
Asunto(s)
Enfermedad Coronaria/prevención & control , Estado Nutricional/fisiología , Adulto , Peso Corporal/fisiología , Enfermedad Coronaria/sangre , Enfermedad Coronaria/epidemiología , Humanos , Hipercolesterolemia/sangre , Hipercolesterolemia/diagnóstico , Hipercolesterolemia/terapia , Hipertensión/sangre , Hipertensión/diagnóstico , Hipertensión/terapia , Lípidos/sangre , Masculino , Persona de Mediana Edad , Moscú/epidemiología , Análisis de Regresión , Factores de RiesgoRESUMEN
An organized community numbering 1563 men aged 20 to 59 years engaged in scientific activity were entered into an experimental and prophylactic study. The intervention measures were exercised in a high risk group with dyslipoproteinemia, borderline hypertension and coronary heart disease (CHD), mainly at the expense of alterations in nutrition. The three-year prophylaxis resulted in a 7-percent decrease in blood plasma cholesterol and a 13-percent fall in triglycerides. The prevalence of arterial hypertension declined by 3 and the excess body weight by 3.7 percent, which led to a 33-percent decrease in CHD risk development calculated with the aid of the R. P. Prochorskas risk logistic function. Advantages of the individual strategy of CHD prevention are discussed.
Asunto(s)
Enfermedad Coronaria/prevención & control , Adulto , Colesterol/sangre , Dieta Reductora , Humanos , Hipertensión/dietoterapia , Lipoproteínas/sangre , Masculino , Persona de Mediana Edad , Factores de Riesgo , Triglicéridos/sangreRESUMEN
In the organized population, 364 male subjects aged 20-59 years (those with dyslipoproteinemias and borderline hypertension and patients with coronary heart disease) were on diet for 6 months, which resulted in a significant drop in plasma cholesterol, triglycerides, systolic and diastolic blood pressures, and body weight by 7.7%, 17%, 3%, 3.7%, and 5.3%, respectively. The portion of fat in the diet was reduced from 40% to 36% of total caloric value and that of sugar was decreased from 13% to 10%, at the same time complex carbohydrates and protein were increased from 8% to 12% and from 15% to 17%, respectively. A multiple stepwise regression analysis was used to define whether different variables were significant in lowering the risk factors.