RESUMEN
OBJECTIVE: Given the presence of a pathological immune response in sporadic vestibular schwannoma (sVS), this study aims to explore the roles of aspirin in minimizing sVS growth in vivo. STUDY DESIGN: Retrospective case review. SETTING: Tertiary care hospital. PATIENTS: People diagnosed with sVS and followed at a tertiary referral center by serial magnetic resonance imaging (MRI) for at least 4 months within the period of January 1980 through April 2012. MAIN OUTCOME MEASURES: Patient use of aspirin and sVS growth rate measured by changes in the largest tumor dimension as noted on serial MRIs RESULTS: Within a set of 689 cases, 347 were followed by serial MRI scans (50.3%); of the latter, 81 took aspirin, of which, 33 demonstrated sVS growth, and 48 did not. Of the 266 nonaspirin users, 154 demonstrated sVS growth, and 112 did not. A significant inverse association was found among aspirin users and sVS growth (odds ratio [OR]: 0.50, 95% confidence interval [CI]: 0.29-0.85), which was not confounded by age or sex. CONCLUSION: Our results suggest a potential therapeutic role of aspirin in inhibiting sVS growth.
Asunto(s)
Aspirina/administración & dosificación , Neuroma Acústico/patología , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios RetrospectivosAsunto(s)
Carcinoma Mucoepidermoide/diagnóstico , Carcinoma Mucoepidermoide/cirugía , Neoplasias Laríngeas/diagnóstico , Neoplasias Laríngeas/cirugía , Anciano , Biopsia , Carcinoma Mucoepidermoide/patología , Carcinoma Mucoepidermoide/radioterapia , Diagnóstico Diferencial , Humanos , Neoplasias Laríngeas/patología , Neoplasias Laríngeas/radioterapia , Laringectomía , Masculino , Disección del Cuello , Estadificación de NeoplasiasAsunto(s)
Condroblastoma/diagnóstico , Neoplasias del Oído/diagnóstico , Neoplasias Craneales/diagnóstico , Hueso Temporal , Adulto , Condroblastoma/patología , Condroblastoma/cirugía , Diagnóstico Diferencial , Neoplasias del Oído/patología , Neoplasias del Oído/cirugía , Dolor de Oído/etiología , Pérdida Auditiva Conductiva/etiología , Humanos , Angiografía por Resonancia Magnética , Masculino , Invasividad Neoplásica , Neoplasias Craneales/patología , Neoplasias Craneales/cirugía , Hueso Temporal/patología , Hueso Temporal/cirugía , Tomografía Computarizada por Rayos XAsunto(s)
Neoplasias Hipofaríngeas/diagnóstico , Neoplasias de Tejido Muscular/diagnóstico , Actinas/análisis , Diagnóstico Diferencial , Estudios de Seguimiento , Granuloma de Células Plasmáticas/diagnóstico , Humanos , Hialina/química , Hipofaringe/patología , Masculino , Persona de Mediana Edad , Enfermedades Faríngeas/diagnósticoAsunto(s)
Amiloidosis/complicaciones , Amiloidosis/diagnóstico , Ronquera/diagnóstico , Ronquera/etiología , Enfermedades de la Laringe/diagnóstico , Enfermedades de la Laringe/etiología , Anciano , Amiloidosis/cirugía , Biopsia , Diagnóstico Diferencial , Ronquera/cirugía , Humanos , Enfermedades de la Laringe/cirugía , Laringoscopía , Masculino , Fumar/efectos adversosAsunto(s)
Fibrosarcoma/diagnóstico , Fibrosarcoma/cirugía , Neoplasias de Cabeza y Cuello/diagnóstico , Neoplasias de Cabeza y Cuello/cirugía , Neoplasias Inducidas por Radiación/diagnóstico , Neoplasias Inducidas por Radiación/cirugía , Adulto , Biopsia , Diagnóstico Diferencial , Diagnóstico por Imagen , Humanos , Masculino , Neoplasias Nasofaríngeas/radioterapia , Disección del CuelloRESUMEN
Foreign body aspiration can be a fatal problem in all groups of ages. However, it is a leading cause of accidental deaths in children. Especially in the pediatric age group, diagnosis can be delayed because of various challenges. Children younger than 3 years carry the highest risk, as they are inclined to explore objects with their mouths. In most cases of inhaled foreign body, a positive history of aspiration is obtained. We are reporting a case of laryngeal foreign body that is mistreated for 1 week as a croup syndrome.
Asunto(s)
Cuerpos Extraños/diagnóstico , Cuerpos Extraños/cirugía , Laringe , Crup/diagnóstico , Diagnóstico Diferencial , Humanos , Lactante , Laringoscopía , MasculinoRESUMEN
OBJECTIVE: Malignant external otitis is a severe infection of the external auditory canal and skull base, which most often affects elderly patients with diabetes mellitus. This disease is still a serious disease associated with cranial nerve complications and high morbidity-mortality rate. Malignant otitis externa requires urgent diagnosis and treatment. The most effective treatment is to control the diabetes and to fight infection with the proper antibiotic and debridement necrotic tissue; sometimes, aggressive surgical management is done. We present our 5-year institutional experience in the management of this disease. The aim of this study was to present our experience with the management of malignant otitis externa. METHODS: All patients' records with malignant otitis externa during the last 5 years (2007-2012) were retrieved and reviewed. Diabetes mellitus profile, erythrocyte sedimentation rate, ear swab for culture and sensitivity, computed tomography, and scintigraphy using technetium 99 and gallium 67 were investigated for all patients. RESULTS: During the last 5 years (2007-2012), 10 patients with the diagnosis of malignant otitis externa were admitted to our clinic for investigation and treatment. There were 7 men and 3 women, all between 64 and 83 years of age, with severe persistent otalgia, purulent otorrhea, granulation tissue in the external auditory canal, and diffuse external otitis, and there were 4 patients with facial nerve palsy. Nine patients were confirmed to have a diabetes, and 4 of these 9 cases just had chronic renal failure and underwent dialysis; the remainder 1 case had no diabetes mellitus, but with chronic renal failure on dialysis. Ear swabs for culture and sensitivity usually revealed Pseudomonas aeruginosa. Local debridement and local and systemic antibiotic treatment were sufficient to control the disease. Facial nerve decompression was done in facial paralysis. Hyperbaric oxygen therapy was performed in facial nervy palsy cases. CONCLUSIONS: Malignant otitis externa is still a serious disease associated with cranial nerve complications and high morbidity-mortality rate. The most effective treatment is to control the diabetes and to fight infection with the proper antibiotic, debridement necrotic tissue, and sometimes aggressive surgical management. Monitoring of therapy response is done through normalization of erythrocyte sedimentation rate, control of diabetes mellitus, and improvement of computed tomography and radioisotope scanning.
Asunto(s)
Infecciones Bacterianas/diagnóstico , Infecciones Bacterianas/terapia , Otitis Externa/diagnóstico , Otitis Externa/terapia , Anciano , Anciano de 80 o más Años , Infecciones Bacterianas/microbiología , Terapia Combinada , Diagnóstico por Imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Otitis Externa/microbiología , Resultado del TratamientoAsunto(s)
Quistes/patología , Quistes/cirugía , Tabique Nasal/cirugía , Enfermedades Nasales/patología , Enfermedades Nasales/cirugía , Complicaciones Posoperatorias/patología , Complicaciones Posoperatorias/cirugía , Adulto , Quistes/diagnóstico , Humanos , Imagen por Resonancia Magnética , Masculino , Enfermedades Nasales/diagnóstico , Complicaciones Posoperatorias/diagnóstico , Tomografía Computarizada por Rayos XAsunto(s)
Quistes Óseos Aneurismáticos/diagnóstico , Quistes Óseos Aneurismáticos/cirugía , Enfermedades Mandibulares/diagnóstico , Enfermedades Mandibulares/cirugía , Adolescente , Biopsia con Aguja Fina , Quistes Óseos Aneurismáticos/patología , Diagnóstico Diferencial , Humanos , Imagen por Resonancia Magnética , Masculino , Enfermedades Mandibulares/patología , Enfermedades de las Parótidas/diagnósticoRESUMEN
Amyloidosis is a disease of unknown etiology characterized by the accumulation of an amorphous proteinaceous material in various organs and tissues of the body. Amyloid goiter is an exceedingly rare pathologic condition due to massive amyloid infiltration of the thyroid tissue. Amyloid goiter occurs in association with both primary and secondary systemic amyloidosis, more commonly in the latter. Preoperatively, it simulates a multinodular goiter, and surgical intervention is often necessary to establish a diagnosis and to relieve compressive symptoms of a neck mass. We present the case of an 85-year-old female patient who presented with a rapidly enlarging goiter. Histologic examination confirmed amyloid goiter.
Asunto(s)
Amiloidosis/diagnóstico , Amiloidosis/cirugía , Bocio/diagnóstico , Bocio/cirugía , Anciano de 80 o más Años , Amiloidosis/patología , Diagnóstico Diferencial , Endoscopía , Femenino , Bocio/patología , Humanos , Tiroidectomía , Tomografía Computarizada por Rayos XRESUMEN
An inflammatory myofibroblastic tumor, previously known as an inflammatory pseudotumor, is an uncommon neoplasm. This tumor, which has characteristic morphologic and immunohistochemical features, is mostly seen in the lung. We present a rare case of an inflammatory myofibroblastic pseudotumor of the parotid gland. A 45-year-old woman presented with a 4-month history of a swelling in her right parotid region. A partial parotidectomy with preservation of the facial nerve branches was performed. The incidence of inflammatory myofibroblastic tumor in the parotid gland is low, and local resection is currently the best treatment. A prolonged postoperative follow-up period is necessary for patients with inflammatory myofibroblastic tumor. Inflammatory myofibroblastic tumor of the parotid gland is discussed with a brief literature review.
Asunto(s)
Granuloma de Células Plasmáticas/diagnóstico , Granuloma de Células Plasmáticas/cirugía , Neoplasias de la Parótida/diagnóstico , Neoplasias de la Parótida/cirugía , Biopsia , Diagnóstico Diferencial , Diagnóstico por Imagen , Femenino , Granuloma de Células Plasmáticas/patología , Humanos , Persona de Mediana Edad , Neoplasias de la Parótida/patologíaAsunto(s)
Neoplasias del Oído/complicaciones , Neoplasias del Oído/diagnóstico , Epistaxis/etiología , Tumor del Glomo Timpánico/complicaciones , Tumor del Glomo Timpánico/diagnóstico , Anciano , Angiografía de Substracción Digital , Medios de Contraste , Diagnóstico Diferencial , Neoplasias del Oído/radioterapia , Femenino , Tumor del Glomo Timpánico/radioterapia , Humanos , Imagen por Resonancia MagnéticaAsunto(s)
Pólipos Nasales/patología , Osificación Heterotópica/patología , Adulto , Biopsia , Femenino , Humanos , Metaplasia , Pólipos Nasales/diagnóstico por imagen , Pólipos Nasales/cirugía , Osificación Heterotópica/diagnóstico por imagen , Osificación Heterotópica/cirugía , Tomografía Computarizada por Rayos XRESUMEN
Extranodal non-Hodgkin lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The most common site of development of primary laryngeal lymphomas is the supraglottic region. In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy. In these cases, larynx lymphoma was the mucosa-associated lymphoid tissue type and located in the supraglottic area.