RESUMEN
This study aimed to evaluate the secondary outcomes of gender and arch and their impact on pain reduction following initial endodontic therapy. 185 medications, including placebo were prepared, and 170 participants completed the trial. Group 1, received a single dose of Paracetamol alone (G-1), Group 2 received combined Ibuprofen/Paracetamol (G-2). Group 3 received combined Mefenamic acid/Paracetamol (G-3), group 4 received combined Diclofenac K/Paracetamol (G-4) and Group 5 received a placebo (G-5). There were no statistically significant differences in pain reduction between males and females whilst there were statistically significant differences between them and the placebo group. All combinations of Paracetamol performed better in pain reduction than the placebo among females, while there were no statistically significant differences among males. In conclusion, there were no differences in pain reduction between males and females, and arch for the tested analgesics taken immediately following initial endodontic therapy in teeth with irreversible pulpitis.
Asunto(s)
Acetaminofén/administración & dosificación , Ibuprofeno/administración & dosificación , Dimensión del Dolor , Dolor Postoperatorio/tratamiento farmacológico , Tratamiento del Conducto Radicular/efectos adversos , Analgésicos no Narcóticos/administración & dosificación , Quimioterapia Combinada , Femenino , Humanos , Masculino , Manejo del Dolor/métodos , Medición de Riesgo , Tratamiento del Conducto Radicular/métodos , Muestreo , Factores Sexuales , Resultado del TratamientoRESUMEN
INTRODUCTION: The present clinical trial aimed to evaluate the efficiency of paracetamol alone and in combination with 3 different nonsteroidal anti-inflammatory drugs for control of post-endodontic pain. METHODS: The inclusion criteria were moderate to severe pain of irreversible pulpitis, by using the Verbal Rating Scale and a 4-10 score on the Numerical Rating Scale, on anterior or premolar teeth, as well as the absence of signs and symptoms of apical periodontitis. One hundred eighty-five trial medications with placebo were prepared, and 170 participants completed the trial. There were 5 groups. P-group received 4 gelatinous capsules of a single dose of paracetamol alone. The IP-group received similar capsules of a single dose of combined ibuprofen/paracetamol. MP-group received combined mefenamic acid/paracetamol, and DP-group received combined diclofenac K/paracetamol. A Plb-group received doubled gelatinous capsules with no medications as a single dose, which had the same weight and appearance as the medicated capsules, to be the placebo. RESULTS: Pain intensity was measured after initial endodontic therapy and instrumentation by using the Verbal Rating Scale and Numerical Rating Scale. IP-group (ibuprofen/paracetamol) had the most pain reduction, followed by DP-group (combined diclofenac K/paracetamol), then MP-group, followed by P-group, whereas Plb-group had the least pain reduction (P < .05). CONCLUSIONS: The combination of ibuprofen/paracetamol, taken immediately after initial endodontic therapy and root canal preparation in teeth with irreversible pulpitis, reduced post-endodontic pain (ClinicalTrials.gov no.: NCT02417337).
Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Dimensión del Dolor/métodos , Dolor Postoperatorio/tratamiento farmacológico , Dolor/tratamiento farmacológico , Preparación del Conducto Radicular/efectos adversos , Acetaminofén/uso terapéutico , Adulto , Anestésicos Locales/administración & dosificación , Diclofenaco/uso terapéutico , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Combinación de Medicamentos , Femenino , Humanos , Ibuprofeno/uso terapéutico , Lidocaína/administración & dosificación , Masculino , Ácido Mefenámico/uso terapéutico , Dolor Postoperatorio/prevención & control , Placebos/administración & dosificación , Pulpitis/terapia , Preparación del Conducto Radicular/instrumentación , Preparación del Conducto Radicular/métodos , Tratamiento del Conducto Radicular/efectos adversos , Tratamiento del Conducto Radicular/métodosRESUMEN
INTRODUCTION: The purpose of the present study was to evaluate postoperative pain after root canal treatment at the Department of Conservative Dentistry, Faculty of Dentistry, University of Khartoum, Sudan. METHODS: Two hundred thirty-four patients were included in this study; age range was 18-62 years. Conventional endodontic treatment was carried out in the included teeth by the undergraduate dental students in a single visit or multiple visits. The chemomechanical preparation of root canals was done by a modified double-flared technique with combination of hand instruments. Postoperative pain was recorded by each patient by using visual analogue scale in well-defined categories at 2 time intervals, 12 hours and 24 hours. RESULTS: Data were analyzed with the chi(2) test. The overall incidence of postoperative pain was 9.0% after 12 hours and 24 hours. Postoperative pain developed in 15.9% of the patients with history of preoperative pain, whereas 7.1% had postoperative pain among those without history of preoperative pain. There was no significant difference in postoperative pain between single-visit and multiple-visit root canal treatment (RCT). CONCLUSIONS: Within the limitations of the present study there was a low incidence of postoperative pain after conventional RCT. No significant difference exists in postoperative pain after single-visit or multiple-visit RCT.